Biflavonoids with cytotoxic and antibacterial activity from Ochna macrocalyx

Tang, Sharon, Bremner, Paul, Kortenkamp, Andreas, Schlage, Christina, Gray, AIexander, Gibbons, S and Heinrich, Michael (2003) Biflavonoids with cytotoxic and antibacterial activity from Ochna macrocalyx. Planta Medica, 69 (3). pp. 247-253. ISSN 0032-0943

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Abstract

Six biflavonoid and related compounds were isolated from the ethanolic extract of Ochna macrocalyx bark. One is a new compound, the isoflavanone dimer dehydroxyhexaspermone C (1). Previously isolated compounds obtained from the bark are biisoflavonoid hexaspermone C (2), tetrahydrofuran derivative ochnone (3), furobenzopyran derivative cordigol (4), and biflavonoids calodenin B (5) and dihydrocalodenin B (6). Although 3 has already been isolated, its spectral data are presented here for the first time. isolated compounds were tested for cytotoxic activity on MCF-7 breast cancer cells using the MTT reduction assay method. Compound 5 showed cytotoxic activity (7 +/- 0.5 muM) and 6 showed moderate cytotoxicity (35 +/- 7 muM). In antibacterial assays performed using three strains of multi-drug resistant (mdr) Staphylococcus aureus (RN4220, XU212 and SA-1199-B) compounds 5 and in particular 6 showed strong antibacterial activity (MICs 5:64, 8,16 mug/mL 6:8, 8, 8 mug/mL, respectively). The ethanolic extract of the bark also showed NF-kappaB inhibitory activity.

Item Type: Article
Uncontrolled Keywords: ochnaceae,ochna macrocalyx,biflavonoids,antibacterial,mdr,cytotoxicity,nf-kappa b,ethnopharmacology,natural-products,kappa-b
Faculty \ School: Faculty of Science > School of Pharmacy
Depositing User: LivePure Connector
Date Deposited: 10 Jul 2020 00:07
Last Modified: 10 Jul 2020 00:07
URI: https://ueaeprints.uea.ac.uk/id/eprint/75990
DOI: 10.1055/s-2003-38478

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