Longitudinal changes in fat mass and the hippocampus

Ambikairajah, Ananthan, Tabatabaei-Jafari, Hossein, Walsh, Erin, Hornberger, Michael ORCID: https://orcid.org/0000-0002-2214-3788 and Cherbuin, Nicolas (2020) Longitudinal changes in fat mass and the hippocampus. Obesity, 28 (7). pp. 1263-1269. ISSN 1930-7381

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OBJECTIVE: This study aimed to investigate cross-sectional and longitudinal associations between fat mass (i.e., body mass index [BMI], waist circumference [WC], and waist to hip ratio [WTHR]) and hippocampal volumes.   METHODS: UK Biobank participants (N = 20,395) aged 40 to 70 years (mean follow-up = 7.66 years), were included and categorized into one of four groups, which represented their baseline fat mass status and trajectory of change by follow-up assessment: normal weight to overweight/obesity, overweight/obesity to normal weight (ON), normal weight stable (NS), or overweight/obesity stable (OS). Regression models used NS (WC < 80 cm in women and < 94 cm in men; WTHR < 0.85 in women and < 0.90 in men; BMI < 25 kg/m2 in women and men) as the reference group. Hippocampal volumes were automatically segmented using the FMRIB Software Library.   RESULTS: Compared with NS, OS (BMI: B = -62.23 [SE = 16.76]; WC: B = -145.56 [SE = 16.97]; WTHR: B = -101.26 [SE = 19.54]) and ON (BMI: B = -61.1 [SE = 30.3]; WC: B = -93.77 [SE = 24.96]; WTHR: B = -69.92 [SE = 26.22]) had significantly lower hippocampal volumes.   CONCLUSIONS: The detrimental effects of overweight/obesity may extend beyond the duration of overweight/obesity itself.

Item Type: Article
Additional Information: © 2020 The Obesity Society.
Uncontrolled Keywords: sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups: Faculty of Medicine and Health Sciences > Research Groups > Mental Health
Faculty of Medicine and Health Sciences > Research Centres > Norwich Institute for Healthy Aging
Faculty of Medicine and Health Sciences > Research Centres > Lifespan Health
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Depositing User: LivePure Connector
Date Deposited: 07 Jul 2020 00:00
Last Modified: 19 Oct 2023 02:42
URI: https://ueaeprints.uea.ac.uk/id/eprint/75922
DOI: 10.1002/oby.22819


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