Quantitative 3D analysis of bone in hip osteoarthritis using clinical computed tomography

Turmezei, Thomas, Treece, Graham M., Gee, Andrew H., Fotiadou, Anastasia F. and Poole, Kenneth E. S. (2015) Quantitative 3D analysis of bone in hip osteoarthritis using clinical computed tomography. European Radiology, 26. 2047–2054. ISSN 0938-7994

[thumbnail of Published_Version]
PDF (Published_Version) - Published Version
Available under License Creative Commons Attribution Non-commercial.

Download (2MB) | Preview


Objective To assess the relationship between proximal femoral cortical bone thickness and radiological hip osteoarthritis using quantitative 3D analysis of clinical computed tomography (CT) data. Methods Image analysis was performed on clinical CT imaging data from 203 female volunteers with a technique called cortical bone mapping (CBM). Colour thickness maps were created for each proximal femur. Statistical parametric mapping was performed to identify statistically significant differences in cortical bone thickness that corresponded with the severity of radiological hip osteoarthritis. Kellgren and Lawrence (K&L) grade, minimum joint space width (JSW) and a novel CT-based osteophyte score were also blindly assessed from the CT data. Results For each increase in K&L grade, cortical thickness increased by up to 25 % in distinct areas of the superolateral femoral head–neck junction and superior subchondral bone plate. For increasing severity of CT osteophytes, the increase in cortical thickness was more circumferential, involving a wider portion of the head–neck junction, with up to a 7 % increase in cortical thickness per increment in score. Results were not significant for minimum JSW. Conclusions These findings indicate that quantitative 3D analysis of the proximal femur can identify changes in cortical bone thickness relevant to structural hip osteoarthritis.

Item Type: Article
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: LivePure Connector
Date Deposited: 02 Jul 2020 00:03
Last Modified: 22 Oct 2022 06:24
URI: https://ueaeprints.uea.ac.uk/id/eprint/75866
DOI: 10.1007/s00330-015-4048-x

Actions (login required)

View Item View Item