Antimycobacterial Coumarins from the Sardinian Giant Fennel (Ferula communis)

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Appendino, Giovanni, Mercalli, Enrico, Fuzzati, Nicola, Arnoldi, Lolita, Stavri, Michael, Gibbons, Simon, Ballero, Mauro and Maxia, Andrea (2004) Antimycobacterial Coumarins from the Sardinian Giant Fennel (Ferula communis). Journal of Natural Products, 67 (12). pp. 2108-2110. ISSN 0163-3864

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Abstract

The structure of a new prenylated coumarin (E-ω-benzoyloxyferulenol, 1b) from the Sardinian giant fennel (Ferula communis) has been confirmed by synthesis. The parent compound ferulenol (1a) showed sub-micromolar antimycobacterial activity, which was partly retained in 1b and in the simplified synthetic analogue 3, but diminished in its ω-hydroxy and ω-acetoxy derivatives (1c and 1d, respectively). The outstanding activity of 1a, its low toxicity, and the evidence for definite structure−activity relationships make this prenylated 4-hydroxycoumarin an interesting antibacterial chemotype worth further investigation.

Item Type:	Article
Faculty \ School:	Faculty of Science > School of Pharmacy (former - to 2024)
Related URLs:	https://pubs.acs.org/doi/10.1021/np04970...
Depositing User:	LivePure Connector
Date Deposited:	01 Jul 2020 00:00
Last Modified:	28 Mar 2025 10:02
URI:	https://ueaeprints.uea.ac.uk/id/eprint/75846
DOI:	10.1021/np049706n

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