Sesquiterpenes from Warburgia ugandensis and their antimycobacterial activity

Wube, Abraham Abebe, Bucar, Franz, Gibbons, Simon and Asres, Kaleab (2005) Sesquiterpenes from Warburgia ugandensis and their antimycobacterial activity. Phytochemistry, 66 (19). pp. 2309-2315. ISSN 0031-9422

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The dichloromethane extract of the stem bark of Warburgia ugandensis afforded three new coloratane sesquiterpenes, namely: 6α,9α-dihydroxy-4(13),7-coloratadien-11,12-dial (1), 4(13),7-coloratadien-12,11-olide (2), and 7β-hydroxy-4(13),8-coloratadien-11,12-olide (3), together with nine known sesquiterpenes, i.e., cinnamolide-3β-acetate (4), muzigadial (5), muzigadiolide (6), 11α-hydroxymuzigadiolide (7), cinnamolide (8), 7α-hydroxy-8-drimen-11,12-olide (9), ugandensolide (10), mukaadial (11), ugandensidial (12), and linoleic acid (13). Their structures were assigned on the basis of 1D and 2D-NMR spectroscopic and GC-MS analysis. The compounds were examined for their antimycobacterial activity against Mycobacterium aurum, M. fortuitum, M. phlei and M. smegmatis; and the active constituents showed MIC values ranged from 4 to128 μg/ml compared to the antibiotic drugs ethambutol (MIC ranged from 0.5 to 8 μg/ml) and isoniazid (MIC ranged from 1 to 4 μg/ml).

Item Type: Article
Faculty \ School: Faculty of Science > School of Pharmacy
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Depositing User: LivePure Connector
Date Deposited: 30 Jun 2020 00:20
Last Modified: 22 Oct 2022 06:23
DOI: 10.1016/j.phytochem.2005.07.018

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