Myristica iowiana phytochemicals as inhibitor of plasmid conjugation in Escherichia coli

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Kwapong, Awo Afi, Soares, Sarah, Teo, Stephen Ping, Stapleton, Paul and Gibbons, Simon (2020) Myristica iowiana phytochemicals as inhibitor of plasmid conjugation in Escherichia coli. Evidence-Based Complementary and Alternative Medicine, 2020. ISSN 1741-427X

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Abstract

Hexane extract and methanol fraction from the stem bark of Myristica lowiana specifically and significantly inhibited the conjugal transfer of the IncW plasmid R7K, a plasmid which harbors ampicillin-, streptomycin-, and spectinomycin-resistant genes. The transfer of this plasmid via the conjugative pilli of Escherichia coli was reduced by 76.5 ± 2.0% and 79.0 ± 1.2% by hexane extract and methanol fraction of M. lowiana, respectively. The hexane extract exhibited significant anti-conjugant activity at a non-cytotoxic concentration of 100 mg/L as assessed against adult human dermal fibroblast cells. The hexane extract and methanol fraction were screened using phytochemical tests, NMR spectroscopy, IR spectroscopy, and high-resolution electrospray ionization mass spectrometry (HRESIMS) and were found to contain terpenoids, sterols, and fatty acids.

Item Type:	Article
Uncontrolled Keywords:	complementary and alternative medicine ,/dk/atira/pure/subjectarea/asjc/2700/2707
Faculty \ School:	Faculty of Science > School of Pharmacy
Related URLs:	http://www.scopus.com/inward/record.url?... https://www.hindawi.com/journals/ecam/20...
Depositing User:	LivePure Connector
Date Deposited:	27 Jun 2020 00:03
Last Modified:	22 Oct 2022 06:23
URI:	https://ueaeprints.uea.ac.uk/id/eprint/75813
DOI:	10.1155/2020/1604638

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