An anti-staphylococcal acylphloroglucinol from Hypericum foliosum

Gibbons, Simon, Moser, Elisabeth, Hausmann, Sebastian, Stavri, Michael, Smith, Eileen and Clennett, Christopher (2005) An anti-staphylococcal acylphloroglucinol from Hypericum foliosum. Phytochemistry, 66 (12). pp. 1472-1475. ISSN 0031-9422

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Abstract

An investigation into the antibacterial properties of Hypericum foliosum Aiton. (Guttiferae) has led to the isolation of a new bioactive acylphloroglucinol natural product which by NMR spectroscopy and mass spectrometry was characterised as 1,3,5-trihydroxy-6-[2‴,3‴-epoxy-3‴-methyl-butyl]-2-[2″-methyl-butanoyl]-4-[3′-methyl-2″-butenyl]-benzene and is described here for the first time. This metabolite was evaluated against a panel of multidrug-resistant strains of Staphylococcus aureus and minimum inhibitory values ranged from 16 to 32 μg/ml.

Item Type: Article
Faculty \ School: Faculty of Science > School of Pharmacy
Related URLs:
Depositing User: LivePure Connector
Date Deposited: 27 Jun 2020 00:03
Last Modified: 27 Jun 2020 00:03
URI: https://ueaeprints.uea.ac.uk/id/eprint/75812
DOI: 10.1016/j.phytochem.2005.04.024

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