An antibacterial hydroxy fusidic acid analogue from Acremonium crotocinigenum

Evans, Liam, Hedger, John N., Brayford, David, Stavri, Michael, Smith, Eileen, O’Donnell, Gemma, Gray, Alexander I., Griffith, Gareth W. and Gibbons, Simon (2006) An antibacterial hydroxy fusidic acid analogue from Acremonium crotocinigenum. Phytochemistry, 67 (19). pp. 2110-2114. ISSN 0031-9422

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A fusidane triterpene, 16-deacetoxy-7-β-hydroxy-fusidic acid (1), was isolated from a fermentation of the mitosporic fungus Acremonium crotocinigenum. Full unambiguous assignment of all 1H and 13C data of 1 was carried out by extensive one- and two-dimensional NMR studies employing HMQC and HMBC spectra. Compound 1 was tested against a panel of multidrug-resistant (MDR) and methicillin-resistant Staphylococcus aureus (MRSA) strains and showed minimum inhibitory concentration values of 16 μg/ml.

Item Type: Article
Faculty \ School: Faculty of Science > School of Pharmacy
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Depositing User: LivePure Connector
Date Deposited: 27 Jun 2020 00:03
Last Modified: 22 Oct 2022 06:23
DOI: 10.1016/j.phytochem.2006.06.033

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