Antibacterial effects of Hypericum ascyron. and Hypericum japonicum. Against multidrug-resistant Staphylococcus aureus

Mu, Qing, Gibbons, Simon, Stavri, Michael, Smith, Eileen, Zhou, Fu-Sheng and Hu, Chang-Qi (2006) Antibacterial effects of Hypericum ascyron. and Hypericum japonicum. Against multidrug-resistant Staphylococcus aureus. Pharmaceutical Biology, 44 (3). pp. 157-159. ISSN 1388-0209

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Abstract

Fractions from a partition of a total extract of Hypericum ascyron. L. and Hypericum japonicum. Thunb. ex Murray were investigated for their antibacterial activity against a strain of multidrug-resistant (MDR) Staphylococcus aureus. possessing the NorA multidrug-efflux transporter, the major characterized MDR pump in this species. The hexane fraction of Hypericum ascyron. and the n.-BuOH fraction of H. japonicum. both showed appreciable antibacterial activities with minimum inhibitory concentration (MIC) values of 128 µg/ml for both fractions. Given the complexity of these extracts and the relevance of the NorA efflux mechanism in clinical isolates of Staphylococcus aureus., these results highlight the potential of the genus Hypericum. as a source of new antibacterial drug-leads.

Item Type:	Article
Faculty \ School:	Faculty of Science > School of Pharmacy
Related URLs:	http://www.tandfonline.com/doi/full/10.1...
Depositing User:	LivePure Connector
Date Deposited:	27 Jun 2020 00:03
Last Modified:	04 Mar 2024 17:56
URI:	https://ueaeprints.uea.ac.uk/id/eprint/75805
DOI:	10.1080/13880200600686079

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