Anti-staphylococcal acylphloroglucinols from Hypericum beanii

Po Shiu, Winnie Ka and Gibbons, Simon (2006) Anti-staphylococcal acylphloroglucinols from Hypericum beanii. Phytochemistry, 67 (23). pp. 2568-2572. ISSN 0031-9422

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As part of an ongoing project to investigate the anti-staphylococcal properties of the Hypericum genus, an acylphloroglucinol, 1,5-dihydroxy-2-(2′-methylpropionyl)-3-methoxy-6-methylbenzene (1), was isolated from the dichloromethane extract of the aerial parts of H. beanii (Guttiferae), together with a minor related acylphloroglucinol 1,5-dihydroxy-2-(2′-methylbutanoyl)-3-methoxy-6-methylbenzene (2) as a mixture in a 5:2 ratio. The known compounds 1,7-dihydroxyxanthone (3), stigmasterol, catechin and shikimic acid were also isolated from this plant. The structures of the compounds were characterized by extensive 1- and 2D NMR spectroscopy and mass spectrometry. The minimum inhibitory concentration (MIC) values the acylphloroglucinol mixture and (3) against a panel of multidrug-resistant strains of Staphylococcus aureus ranged from 16–32 μg/ml to 128–256 μg/ml, respectively.

Item Type: Article
Faculty \ School: Faculty of Science > School of Pharmacy
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Depositing User: LivePure Connector
Date Deposited: 27 Jun 2020 00:02
Last Modified: 22 Oct 2022 06:23
DOI: 10.1016/j.phytochem.2006.09.037

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