Gedunin, a limonoid from Xylocarpus granatum, inhibits the growth of CaCo-2 colon cancer cell line In Vitro

Uddin, Shaikh J., Nahar, Lutfun, Shilpi, Jamil A., Shoeb, Mohammad, Borkowski, Tomasz, Gibbons, Simon, Middleton, Moira, Byres, Maureen and Sarker, Satyajit D. (2007) Gedunin, a limonoid from Xylocarpus granatum, inhibits the growth of CaCo-2 colon cancer cell line In Vitro. Phytotherapy Research, 21 (8). pp. 757-761. ISSN 0951-418X

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Abstract

Xylocarpus granatum J. König (Meliaceae), commonly known as ‘dhundul’, is a Bangladeshi mangrove tree, and well distributed in a number of other countries of south‐east Asia, Australia and east Africa. Traditionally, X. granatum has been used as an astringent and febrifuge, and also for the treatment of fever, malaria, thrush, cholera, dysentery and diarrhoea in many countries including Bangladesh. Two limonoids, gedunin and 1α ‐hydroxy‐1,2‐dihydrogedunin, the latter being new, have been isolated from the bark of Xylocarpus granatum by reversed‐phase preparative HPLC, and the structures were confirmed by spectroscopic means. The cytotoxic potential of gedunin has been evaluated by the Promega's CellTiter 96 non‐radioactive cell proliferation assay using the CaCo‐2 colon cancer cell line (IC50 = 16.83 µm ). A summary of the biological activities of gedunin reported to date is also presented.

Item Type: Article
Faculty \ School: Faculty of Science > School of Pharmacy
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Depositing User: LivePure Connector
Date Deposited: 19 Jun 2020 00:07
Last Modified: 19 Jun 2020 00:07
URI: https://ueaeprints.uea.ac.uk/id/eprint/75698
DOI: 10.1002/ptr.2159

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