Polyisoprenylated Benzoylphloroglucinol Derivatives from Hypericum sampsonii
Xiao, Zhi Yong, Mu, Qing, Shiu, Winnie Ka Po, Zeng, Yi Han and Gibbons, Simon (2007) Polyisoprenylated Benzoylphloroglucinol Derivatives from Hypericum sampsonii. Journal of Natural Products, 70 (11). pp. 1779-1782. ISSN 0163-3864
Full text not available from this repository.Abstract
Bioassay-directed fractionation using multidrug-resistant (MDR) Staphylococcus aureus resulted in the isolation of four new polyprenylated benzophloroglucinol derivatives, sampsoniones N–Q (1–4), and four known compounds, 7-epiclusianone (5) and sampsoniones B, L, and R, from the roots of Hypericum sampsonii. The structures of these compounds were established by analysis of spectroscopic data, and the structures of 4 and 5 were determined by single-crystal X-ray diffraction crystallography. In the bioassay, 7-epiclusianone (5) showed promising activity with a minimum inhibitory concentration (MIC) of 7.3 µM against the NorA overexpressing MDR S. aureus strain SA-1199B; the positive control antibiotic norfloxacin showed activity at MIC 100 µM.
Item Type: | Article |
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Faculty \ School: | Faculty of Science > School of Pharmacy |
Related URLs: | |
Depositing User: | LivePure Connector |
Date Deposited: | 19 Jun 2020 00:07 |
Last Modified: | 11 Aug 2022 17:14 |
URI: | https://ueaeprints.uea.ac.uk/id/eprint/75697 |
DOI: | 10.1021/np0704147 |
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