Polyisoprenylated benzoylphloroglucinol derivatives from Hypericum sampsonii

Xiao, Zhi Yong, Mu, Qing, Shiu, Winnie Ka Po, Zeng, Yi Han and Gibbons, Simon (2007) Polyisoprenylated benzoylphloroglucinol derivatives from Hypericum sampsonii. Journal of Natural Products, 70 (11). pp. 1779-1782. ISSN 0163-3864

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Bioassay-directed fractionation using multidrug-resistant (MDR) Staphylococcus aureus resulted in the isolation of four new polyprenylated benzophloroglucinol derivatives, sampsoniones N–Q (1–4), and four known compounds, 7-epiclusianone (5) and sampsoniones B, L, and R, from the roots of Hypericum sampsonii. The structures of these compounds were established by analysis of spectroscopic data, and the structures of 4 and 5 were determined by single-crystal X-ray diffraction crystallography. In the bioassay, 7-epiclusianone (5) showed promising activity with a minimum inhibitory concentration (MIC) of 7.3 µM against the NorA overexpressing MDR S. aureus strain SA-1199B; the positive control antibiotic norfloxacin showed activity at MIC 100 µM.

Item Type: Article
Faculty \ School: Faculty of Science > School of Pharmacy
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Depositing User: LivePure Connector
Date Deposited: 19 Jun 2020 00:07
Last Modified: 19 Jul 2023 10:30
URI: https://ueaeprints.uea.ac.uk/id/eprint/75697
DOI: 10.1021/np0704147

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