Polyisoprenylated Benzoylphloroglucinol Derivatives from Hypericum sampsonii

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Xiao, Zhi Yong, Mu, Qing, Shiu, Winnie Ka Po, Zeng, Yi Han and Gibbons, Simon (2007) Polyisoprenylated Benzoylphloroglucinol Derivatives from Hypericum sampsonii. Journal of Natural Products, 70 (11). pp. 1779-1782. ISSN 0163-3864

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Abstract

Bioassay-directed fractionation using multidrug-resistant (MDR) Staphylococcus aureus resulted in the isolation of four new polyprenylated benzophloroglucinol derivatives, sampsoniones N–Q (1–4), and four known compounds, 7-epiclusianone (5) and sampsoniones B, L, and R, from the roots of Hypericum sampsonii. The structures of these compounds were established by analysis of spectroscopic data, and the structures of 4 and 5 were determined by single-crystal X-ray diffraction crystallography. In the bioassay, 7-epiclusianone (5) showed promising activity with a minimum inhibitory concentration (MIC) of 7.3 µM against the NorA overexpressing MDR S. aureus strain SA-1199B; the positive control antibiotic norfloxacin showed activity at MIC 100 µM.

Item Type:	Article
Faculty \ School:	Faculty of Science > School of Pharmacy
Related URLs:	https://pubs.acs.org/doi/10.1021/np07041...
Depositing User:	LivePure Connector
Date Deposited:	19 Jun 2020 00:07
Last Modified:	22 Oct 2022 06:20
URI:	https://ueaeprints.uea.ac.uk/id/eprint/75697
DOI:	10.1021/np0704147

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