The phenolic diterpene totarol inhibits multidrug efflux pump activity in Staphylococcus aureus

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Smith, Eileen C. J., Kaatz, Glenn W., Seo, Susan M., Wareham, Neale, Williamson, Elizabeth M. and Gibbons, Simon (2007) The phenolic diterpene totarol inhibits multidrug efflux pump activity in Staphylococcus aureus. Antimicrobial Agents and Chemotherapy, 51 (12). pp. 4480-4483. ISSN 0066-4804

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Abstract

The phenolic diterpene totarol had good antimicrobial activity against effluxing strains of Staphylococcus aureus. Subinhibitory concentrations reduced the MICs of selected antibiotics, suggesting that it may also be an efflux pump inhibitor (EPI). A totarol-resistant mutant that overexpressed norA was created to separate antimicrobial from efflux inhibitory activity. Totarol reduced ethidium efflux from this strain by 50% at 15 μM (1/4× MIC), and combination studies revealed marked reductions in ethidium MICs. These data suggest that totarol is a NorA EPI as well as an antistaphylococcal antimicrobial agent.

Item Type:	Article
Faculty \ School:	Faculty of Science > School of Pharmacy (former - to 2024)
Related URLs:	https://AAC.asm.org/content/51/12/4480
Depositing User:	LivePure Connector
Date Deposited:	19 Jun 2020 00:07
Last Modified:	28 Mar 2025 10:01
URI:	https://ueaeprints.uea.ac.uk/id/eprint/75696
DOI:	10.1128/AAC.00216-07

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