Assessment of the antibacterial activity of phenylethanoid glycosides from Phlomis lanceolata against multiple-drug-resistant strains of Staphylococcus aureus

Nazemiyeh, Hossein, Rahman, M. Mukhlesur, Gibbons, Simon, Nahar, Lutfun, Delazar, Abbas, Ghahramani, Mohammed-Ali, Talebpour, Amir-Hossein and Sarker, Satyajit D. (2008) Assessment of the antibacterial activity of phenylethanoid glycosides from Phlomis lanceolata against multiple-drug-resistant strains of Staphylococcus aureus. Journal of Natural Medicines, 62 (1). pp. 91-95. ISSN 1340-3443

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Abstract

Three phenylethanoid glycosides, forsythoside B (1), phlinoside C (2) and verbascoside (3), were isolated from the methanol extract of the leaves of Phlomis lanceolata, an Iranian medicinal plant, by reversed-phase preparative high-performance liquid chromatography (HPLC), and the structures of these compounds were elucidated conclusively by ultraviolet (UV), mass spectrometry (MS) and a series of 1D and 2D nuclear magnetic resonance (NMR) analyses. The antibacterial properties of 1–3 against five multi-drug-resistant (MDR) strains of Staphylococcus aureus have been assessed by the rapid and robust microtitre-plate-based serial dilution method. While compounds 1 and 3 showed considerable activities against all five strains, compound 2 was inactive at the test concentrations.

Item Type: Article
Faculty \ School: Faculty of Science > School of Pharmacy
Related URLs:
Depositing User: LivePure Connector
Date Deposited: 19 Jun 2020 00:07
Last Modified: 19 Jun 2020 00:07
URI: https://ueaeprints.uea.ac.uk/id/eprint/75690
DOI: 10.1007/s11418-007-0194-z

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