Acacetin—A simple flavone exhibiting diverse pharmacological activities

Semwal, Ruchi Badoni, Semwal, Deepak Kumar, Combrinck, Sandra, Trill, Jeanne, Gibbons, Simon and Viljoen, Alvaro (2019) Acacetin—A simple flavone exhibiting diverse pharmacological activities. Phytochemistry Letters, 32. pp. 56-65. ISSN 1874-3900

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Abstract

Acacetin (5,7-dihydroxy-4-methoxyflavone) is a naturally occurring flavonoid, known to possess numerous pharmacological properties, including neuroprotective, cardioprotective, anticancer, anti-inflammatory, antidiabetic, and antimicrobial activities. The molecule is widespread throughout the Plant Kingdom, but is particularly abundant in the Asteraceae, Euphorbiaceae, Passifloraceae, Lamiaceae and Malvaceae families. It has been shown to exhibit strong inhibitory effects against glutathione reductase, cyclo-oxygenase, acetylcholinesterase, aldose reductase and xanthine oxidase enzymes. A comprehensive overview of the potential therapeutic applications of acacetin was prepared after collating selected peer-reviewed papers, accessed from online scientific databases, specifically PubMed, Web of Science and Scopus. The mechanism of action, dose forms and structure-activity relationships of the molecule are some of the aspects discussed in the review, to facilitate further research and use of this molecule.

Item Type: Article
Faculty \ School: Faculty of Science > School of Pharmacy
Depositing User: LivePure Connector
Date Deposited: 19 Jun 2020 00:05
Last Modified: 19 Jun 2020 00:05
URI: https://ueaeprints.uea.ac.uk/id/eprint/75665
DOI: 10.1016/j.phytol.2019.04.021

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