Melilotoside derivatives from Artemisia splendens (Asteraceae)

Afshar, Fariba H., Delazar, Abbas, Nazemiyeh, Hossein, Nahar, Lutfun, Moghaddam, Sedigheh B., Mbaebie, Blessing O., Gibbons, Simon and Sarker, Satyajit D. (2017) Melilotoside derivatives from Artemisia splendens (Asteraceae). Records of Natural Products, 11 (1). pp. 43-50. ISSN 1307-6167

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Abstract

A combination of solid-phase-extraction (SPE) and reversed-phase preparative high-performance liquid chromatography (prep-HPLC) of the methanolic extract of the aerial parts of Artemisia splendens (common name: “Asia Minor Wormwood”), an endemic Iranian species, afforded Z- and E-melilotosides (1 and 2), Z- and E-4-methoxy-melilotosides (3 and 4), and a new dimer, bis-ortho-Z-melilotoside (5, named: splendenoside). Whilst the structures of these compounds (1-5) were elucidated unequivocally by spectroscopic means, the in vitro free-radical-scavenging property of 1-5 was determined by the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay. This is the first report on the occurrence of any melilotoside derivatives in the genus Artemisia.

Item Type: Article
Uncontrolled Keywords: 2,2-diphenyl-1-picrylhydrazyl (dpph),artemisia splendens,asteraceae,free-radical scavenger,melilotoside,splendenoside,pharmacology,drug discovery,plant science,organic chemistry ,/dk/atira/pure/subjectarea/asjc/3000/3004
Faculty \ School: Faculty of Science > School of Pharmacy
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Depositing User: LivePure Connector
Date Deposited: 18 Jun 2020 00:02
Last Modified: 18 Jun 2020 00:02
URI: https://ueaeprints.uea.ac.uk/id/eprint/75651
DOI:

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