Volatile organic compounds associated with diagnosis and disease characteristics in asthma – A systematic review

Peel, Adam M., Wilkinson, Maxim, Sinha, Ashnish, Loke, Yoon K., Fowler, Stephen J. and Wilson, Andrew M. (2020) Volatile organic compounds associated with diagnosis and disease characteristics in asthma – A systematic review. Respiratory Medicine, 169. ISSN 0954-6111

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Background Metabolomics refers to study of the metabolome, the entire set of metabolites produced by a biological system. The application of metabolomics to exhaled breath samples - breathomics - is a rapidly growing field with potential application to asthma diagnosis and management. Objectives We aimed to review the adult asthma breathomic literature and present a comprehensive list of volatile organic compounds identified by asthma breathomic models. Methods We undertook a systematic search for literature on exhaled volatile organic compounds in adult asthma. We assessed the quality of studies and performed a qualitative synthesis. Results We identified twenty studies; these were methodologically heterogenous with a variable risk of bias. Studies almost universally reported breathomics to be capable of differentiating - with moderate or greater accuracy - between samples from healthy controls and those with asthma; and to be capable of phenotyping disease. However, there was little concordance in the compounds upon which discriminatory models were based. Conclusion Results to-date are promising but validation in independent prospective cohorts is needed. This may be challenging given the high levels of inter-individual variation. However, large-scale, multi-centre studies are underway and validation efforts have been aided by the publication of technical standards likely to increase inter-study comparability. Successful validation of breathomic models for diagnosis and phenotyping would constitute an important step towards personalised medicine in asthma.

Item Type: Article
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
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Depositing User: LivePure Connector
Date Deposited: 20 May 2020 00:14
Last Modified: 19 Oct 2020 23:52
URI: https://ueaeprints.uea.ac.uk/id/eprint/75251
DOI: 10.1016/j.rmed.2020.105984

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