Moderators of cognitive outcomes from an exercise programme in people with mild to moderate dementia

Smith, Toby ORCID:, Mistry, Dipesh, Lee, Hopin, Dosanji, Sukhdeep, Finnegan, Susanne, Fordham, Bethany, Nichols, Vivien, Sheehan, Bart and Lamb, Sarah (2020) Moderators of cognitive outcomes from an exercise programme in people with mild to moderate dementia. Journal of the American Geriatrics Society, 68 (9). pp. 2095-2100. ISSN 0002-8614

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BACKGROUND/OBJECTIVES: Our aim was to estimate whether baseline participant variables were able to moderate the effect of an exercise intervention on cognition in patients with mild to moderate dementia. DESIGN: Subgroup analysis of a multicenter pragmatic randomized controlled trial. SETTING: Community-based gym/rehabilitation centers. PARTICIPANTS: A total of 494 community-dwelling participants with mild to moderate dementia. INTERVENTION: Participants were randomized to a moderate- to high-intensity aerobic and strength exercise program or a usual care control group. Experimental group participants attended twice weekly 60- to 90-minute gym sessions for 4 months. Participants were prescribed home exercises for an additional hour per week during the supervised period and 150 minutes each week after the supervised period. MEASUREMENTS: Multilevel regression model analyses were undertaken to identify individual moderators of cognitive function measured through the Alzheimer Disease Assessment Scale-Cognitive Subscale score at 12 months. RESULTS: When tested for a formal interaction effect, only cognitive function assessed by the baseline number cancellation test demonstrated a statistically significant interaction effect (−2.7 points; 95% confidence interval = −5.14 to −0.21). CONCLUSION: People with worse number cancellation test scores may experience greater progression of cognitive decline in response to a moderate- to high-intensity exercise program. Further analyses to examine whether these findings can be replicated in planned sufficiently powered analyses are indicated.

Item Type: Article
Uncontrolled Keywords: demential and physical activity trial,cognitive function,dementia,physical activity,prediction,geriatrics and gerontology ,/dk/atira/pure/subjectarea/asjc/2700/2717
Faculty \ School: Faculty of Medicine and Health Sciences > School of Health Sciences
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Depositing User: LivePure Connector
Date Deposited: 01 May 2020 00:06
Last Modified: 22 Oct 2022 06:05
DOI: 10.1111/jgs.16552

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