TIMP-3 and endocrine therapy of breast cancer: an apoptosis connection emerges

Edwards, Dylan R. ORCID: https://orcid.org/0000-0002-3292-2064 (2004) TIMP-3 and endocrine therapy of breast cancer: an apoptosis connection emerges. The Journal of Pathology, 202 (4). pp. 391-394. ISSN 0022-3417

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Abstract

The tissue inhibitors of metalloproteinases (TIMPs) control the activities of matrix metalloproteinases (MMPs) and as such, they have been recognized as potential suppressors of angiogenesis and tumour invasion and metastasis. However, TIMP-3 has several unique properties that set it apart from other TIMPs, including its ability to bind to extracellular matrix, inhibit related adamalysin metalloproteinases (ADAMs), and induce apoptosis. New data suggest that high levels of TIMP-3 mRNAs in human breast tumours are associated with success of adjuvant endocrine therapy, but not chemotherapy.

Item Type:	Article
Uncontrolled Keywords:	sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School:	Faculty of Science > School of Biological Sciences
Depositing User:	EPrints Services
Date Deposited:	01 Oct 2010 13:37
Last Modified:	06 Mar 2023 16:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/749
DOI:	10.1002/path.1548

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