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Aldholmi, Mohammed, Wilkinson, Barrie and Ganesan, A 
ORCID: https://orcid.org/0000-0003-4862-7999
(2020)
Epigenetic modulation of secondary metabolite profiles in Aspergillus calidoustus and Aspergillus westerdijkiae through histone deacetylase (HDAC) inhibition by vorinostat.
Journal of Antibiotics, 73 (6).
410–413.
ISSN 0021-8820
Abstract
The effects of epigenetic modulation on secondary metabolite biosynthesis were investigated with five Aspergillus species cultured in the presence of either the DNA methyltransferase inhibitor 5-azacitidine or the histone deacetylase inhibitor vorinostat. With Aspergillus calidoustus and Aspergillus westerdijkiae, fermentation in the presence of vorinostat (100 μM) induced significant changes in secondary metabolite profile with examples of both induction and repression. We identified putative biosynthetic gene clusters for emericellamide in A. calidoustus and ochratoxin in A. westerdijkiae. A substantial induction in production levels was observed for two secondary metabolites: the diketopiperazine alkaloid phenylahistin in A. calidoustus and the polyketide penicillic acid in A. westerdijkiae, indicating the potential of epigenetic regulation for the activation of silent fungal biosynthetic pathways.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | fungus,ochratoxin,pathway,penicillic acid,product,drug discovery,pharmacology ,/dk/atira/pure/subjectarea/asjc/3000/3002 |
| Faculty \ School: | Faculty of Science > School of Pharmacy Faculty of Science > School of Chemistry |
| UEA Research Groups: | Faculty of Science > Research Groups > Chemical Biology and Medicinal Chemistry (former - to 2021) |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 17 Apr 2020 00:51 |
| Last Modified: | 22 Oct 2022 05:59 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/74773 |
| DOI: | 10.1038/s41429-020-0286-5 |
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