Intake and metabolism of n-3 and n-6 PUFA: Nutritional implications for cardiometabolic diseases

Schulze, Matthias, Minihane, Anne-Marie, Saleh, Rasha and Risérus, Ulf (2020) Intake and metabolism of n-3 and n-6 PUFA: Nutritional implications for cardiometabolic diseases. The Lancet Diabetes & Endocrinology. ISSN 2213-8587 (In Press)

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Abstract

Prospective observational studies support a role of long-chain n-3 PUFA in the primary prevention of atherosclerotic cardiovascular disease, however, RCTs have often reported neutral findings. There has been also a long history of debate about potential harmful effects of high n-6 PUFA intake, although this notion is not supported by prospective observational studies or RCTs. Health effects of dietary PUFA may be influenced by delta-5 and delta-6 desaturases, key enzymes in the metabolism of PUFA. The activity of these enzymes and its modulation by variants in encoding genes (FADS1-2-3 gene cluster) are linked to several cardiometabolic traits. This review will furthermore consider non-genetic determinants of desaturase activity, which have the potential to modify tissue PUFA availability. Finally, it will discuss the consequences of altered desaturase activity in the context of PUFA intake, i.e. gene-diet interactions, and their clinical and public health implications

Item Type: Article
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: LivePure Connector
Date Deposited: 16 Apr 2020 00:45
Last Modified: 11 Jul 2020 00:09
URI: https://ueaeprints.uea.ac.uk/id/eprint/74758
DOI:

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