Phosphorylation-regulated activation of the Arabidopsis RRS1-R/RPS4 immune receptor complex reveals two distinct effector recognition mechanisms

Guo, Hailong, Ahn, Hee-kyung ORCID: https://orcid.org/0000-0002-8884-0156, Sklenar, Jan, Huang, Jianhua, Ma, Yan, Ding, Pingtao, Menke, Frank L.h. ORCID: https://orcid.org/0000-0003-2490-4824 and Jones, Jonathan D. G. (2020) Phosphorylation-regulated activation of the Arabidopsis RRS1-R/RPS4 immune receptor complex reveals two distinct effector recognition mechanisms. Cell Host & Microbe, 27 (5). 769-781.e6. ISSN 1931-3128

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Abstract

The Arabidopsis RRS1-R/RPS4 immune receptor complex responds to bacterial effectors AvrRps4 and PopP2. Guo et al. show that effector-enhanced RRS1 N- and C-terminal proximity comprises a critical reconfiguration step involved in derepression of the complex. Further, RRS1-R C-terminal phosphorylation-dependent conformational reconfigurations distinguish responsiveness to the two effectors.

Item Type: Article
Additional Information: Acknowledgements: We thank the Gatsby Foundation (UK) for funding to the Jones lab. We highly appreciate comments from anonymous reviewers which helped us significantly to improve the manuscript. We gratefully acknowledge former lab members, especially Dr. Kee Hoon Sohn, Dr. Sung Un Huh, and Dr. Panagiotis F. Sarris for previous work that provided important background information for this research report. The authors thank Mark Youles in TSL Synbio for his excellent support with Golden Gate cloning and for providing modules. H.G. and H.-K.A. were supported by ERC Advanced Grant "ImmunitybyPairDesign". Y.M. was supported by Biotechnology and Biological Sciences Research Council (BBSRC) grant BB/M008193/1. P.D. was supported by European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie Actions (grant 656243).
Uncontrolled Keywords: acetylation,effector-triggered immunity,integrated decoy,paired nlr immune receptors,phosphorylation,plant-disease resistance,parasitology,microbiology,virology ,/dk/atira/pure/subjectarea/asjc/2400/2405
Faculty \ School:
Faculty of Science > School of Biological Sciences
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Depositing User: LivePure Connector
Date Deposited: 09 Apr 2020 00:50
Last Modified: 24 Sep 2022 05:44
URI: https://ueaeprints.uea.ac.uk/id/eprint/74743
DOI: 10.1016/j.chom.2020.03.008

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