Edwards, Marcus, White, Gaye, Butt, Julea ORCID: https://orcid.org/0000-0002-9624-5226, Richardson, David
ORCID: https://orcid.org/0000-0002-6847-1832 and Clarke, Tom
ORCID: https://orcid.org/0000-0002-6234-1914
(2020)
The crystal structure of a biological insulated transmembrane molecular wire.
Cell, 181 (3).
665-673.e10.
ISSN 0092-8674
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Abstract
A growing number of bacteria are recognized to conduct electrons across their cell envelope, and yet molecular details of the mechanisms supporting this process remain unknown. Here, we report the atomic structure of an outer membrane spanning protein complex, MtrAB, that is representative of a protein family known to transport electrons between the interior and exterior environments of phylogenetically and metabolically diverse microorganisms. The structure is revealed as a naturally insulated biomolecular wire possessing a 10-heme cytochrome, MtrA, insulated from the membrane lipidic environment by embedding within a 26 strand β-barrel formed by MtrB. MtrAB forms an intimate connection with an extracellular 10-heme cytochrome, MtrC, which presents its hemes across a large surface area for electrical contact with extracellular redox partners, including transition metals and electrodes.
Item Type: | Article |
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Uncontrolled Keywords: | decaheme,electrogenic bacteria,extracellular electron transfer,geobacter,iron oxidation,metal reduction,outer membrane protein,porin-cytochrome complex,respiration,shewanella,biochemistry, genetics and molecular biology(all) ,/dk/atira/pure/subjectarea/asjc/1300 |
Faculty \ School: | Faculty of Science > School of Biological Sciences Faculty of Science > School of Chemistry Faculty of Science > School of Natural Sciences |
Related URLs: | |
Depositing User: | LivePure Connector |
Date Deposited: | 25 Mar 2020 01:33 |
Last Modified: | 20 Dec 2022 23:34 |
URI: | https://ueaeprints.uea.ac.uk/id/eprint/74613 |
DOI: | 10.1016/j.cell.2020.03.032 |
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