Nucleotide second messengers in bacterial decision making

Thompson, Catriona and Malone, Jacob ORCID: (2020) Nucleotide second messengers in bacterial decision making. Current Opinion in Microbiology, 55. pp. 34-39. ISSN 1369-5274

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Since the initial discovery of bacterial nucleotide second messengers (NSMs), we have made huge progress towards understanding these complex signalling networks. Many NSM networks contain dozens of metabolic enzymes and binding targets, whose activity is tightly controlled at every regulatory level. They function as global regulators and in specific signalling circuits, controlling multiple aspects of bacterial behaviour and development. Despite these advances there is much still to discover, with current research focussing on the molecular mechanisms of signalling circuits, the role of the environment in controlling NSM pathways and attempts to understand signalling at the whole cell/community level. Here we examine recent developments in the NSM signalling field and discuss their implications for understanding this important driver of microbial behaviour.

Item Type: Article
Faculty \ School: Faculty of Science > School of Biological Sciences
UEA Research Groups: Faculty of Science > Research Groups > Molecular Microbiology
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Depositing User: LivePure Connector
Date Deposited: 24 Mar 2020 01:52
Last Modified: 07 Apr 2023 06:30
DOI: 10.1016/j.mib.2020.02.006

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