Trade-off between somatic and germline repair in a vertebrate supports the "expensive germ line" hypothesis

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Chen, Hwei-Yen, Jolly, Cecile, Bublys, Kasparas, Marcu, Daniel ORCID: https://orcid.org/0000-0002-2151-5850 and Immler, Simone (2020) Trade-off between somatic and germline repair in a vertebrate supports the "expensive germ line" hypothesis. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 117 (16). pp. 8973-8979. ISSN 1091-6490

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Abstract

The disposable soma theory is a central tenet of the biology of aging where germline immortality comes at the cost of an aging soma [T. B. L. Kirkwood, Nature 270, 301–304 (1977); T. B. L. Kirkwood, Proc. R. Soc. Lond. B Biol. Sci. 205, 531–546 (1979); T. B. L. Kirkwood, S. N. Austad, Nature 408, 233–238 (2000)]. Limited resources and a possible trade-off between the repair and maintenance of the germ cells and growth and maintenance of the soma may explain the deterioration of the soma over time. Here we show that germline removal allows accelerated somatic healing under stress. We tested “the expensive germ line” hypothesis by generating germline-free zebrafish Danio rerio and testing the effect of the presence and absence of the germ line on somatic repair under benign and stressful conditions. We exposed male fish to sublethal low-dose ionizing radiation, a genotoxic stress affecting the soma and the germ line, and tested how fast the soma recovered following partial fin ablation. We found that somatic recovery from ablation occurred substantially faster in irradiated germline-free fish than in the control germline-carrying fish where somatic recovery was stunned. The germ line did show signs of postirradiation recovery in germline-carrying fish in several traits related to offspring number and fitness. These results support the theoretical conjecture that germline maintenance is costly and directly trades off with somatic maintenance.

Item Type: Article
Faculty \ School: Faculty of Science > School of Biological Sciences
UEA Research Groups: Faculty of Science > Research Groups > Organisms and the Environment
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Depositing User: LivePure Connector
Date Deposited: 20 Mar 2020 01:28
Last Modified: 13 May 2023 07:30
URI: https://ueaeprints.uea.ac.uk/id/eprint/74558
DOI: 10.1073/pnas.1918205117

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