Dementia diagnosis in seven languages: the Addenbrooke’s Cognitive Examination-III in India

Mekala, Shailaja, Paplikar, Avanthi, Mioshi, Eneida, Kaul, Subhash, Gollahalli, Divyaraj, Coughlan, Gillian, Ellajosyula, Ratnavalli, Jala, Sireesha, Menon, Ramshekhar N., Narayanan, Jwala, Narayan, Sunil, Aghoram, Rajeswari, Nehra, Ashima, Rajan, Amulya, Sabnis, Prerna, Singh, Sonia, Tripathi, Manjari, Verma, Mansi, Saru, Lekha V., Hodges, John R. and Alladi, Suvarna (2020) Dementia diagnosis in seven languages: the Addenbrooke’s Cognitive Examination-III in India. Archives of Clinical Neuropsychology, 35 (5). 528–538. ISSN 0887-6177

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OBJECTIVE: With the rising burden of dementia globally, there is a need to harmonize dementia research across diverse populations. The Addenbrooke's Cognitive Examination-III (ACE-III) is a well-established cognitive screening tool to diagnose dementia. But there have been few efforts to standardize the use of ACE-III across cohorts speaking different languages. The present study aimed to standardize and validate ACE-III across seven Indian languages and to assess the diagnostic accuracy of the test to detect dementia and mild cognitive impairment (MCI) in the context of language heterogeneity.  METHODS: The original ACE-III was adapted to Indian languages: Hindi, Telugu, Kannada, Malayalam, Urdu, Tamil, and Indian English by a multidisciplinary expert group. The ACE-III was standardized for use across all seven languages. In total, 757 controls, 242 dementia, and 204 MCI patients were recruited across five cities in India for the validation study. Psychometric properties of adapted versions were examined and their sensitivity and specificity were established.  RESULTS: The sensitivity and specificity of ACE-III in identifying dementia ranged from 0.90 to 1, sensitivity for MCI ranged from 0.86 to 1, and specificity from 0.83 to 0.93. Education but not language was found to have an independent effect on ACE-III scores. Optimum cut-off scores were established separately for low education (≤10 years of education) and high education (>10 years of education) groups.  CONCLUSIONS: The adapted versions of ACE-III have been standardized and validated for use across seven Indian languages, with high diagnostic accuracy in identifying dementia and MCI in a linguistically diverse context.

Item Type: Article
Uncontrolled Keywords: cognition,dementia,languages,mild cognitive impairment,screening test,neuropsychology and physiological psychology,clinical psychology,psychiatry and mental health,sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/3200/3206
Faculty \ School: Faculty of Medicine and Health Sciences > School of Health Sciences
Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups: Faculty of Medicine and Health Sciences > Research Groups > Dementia & Complexity in Later Life
Faculty of Medicine and Health Sciences > Research Centres > Norwich Institute for Healthy Aging
Faculty of Medicine and Health Sciences > Research Centres > Lifespan Health
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Depositing User: LivePure Connector
Date Deposited: 13 Feb 2020 05:40
Last Modified: 01 Nov 2023 02:13
DOI: 10.1093/arclin/acaa013

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