Organometallic iridium arene compounds: The effects of C-donor ligands on anticancer activity

Lord, Rianne M. ORCID: and McGowan, Patrick C. (2019) Organometallic iridium arene compounds: The effects of C-donor ligands on anticancer activity. Chemistry Letters, 48 (8). pp. 916-924. ISSN 0366-7022

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In the past decade, libraries of iridium organometallic arene compounds have expanded rapidly, with the majority of their applications aimed towards effective catalysts and potential anti-cancer drug candidates. Researchers have begun to adapt the traditional “piano-stool” structures to include different bidentate ligands, ancillary ligands and extend the aromaticity and functionality of the arene substituent, all in the hope to optimize their activities and allow the determination of structure activity relationships. Many of the complexes incorporate N- and O-donor ligands, but more recently, these structures have been expanded to include C-donor ligands such as cyclometalated bidentate ligands and N-heterocyclic carbenes. This mini-review highlights the recent and ongoing research in C-donor iridium arene complexes, and discusses their importance as potential anticancer drugs.

Item Type: Article
Uncontrolled Keywords: anticancer,bioinorganic chemistry,iridium arene complexes,half-sandwich rhodium(iii),in-vitro cytotoxicity,cyclic-pi-perimeter,bodipy-based ru(ii),complexes synthesis,molecular-structure,antitumor complexes,ir(iii) complexes,ruthenium(ii) complexes,escherichia-coli,sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School: Faculty of Science > School of Chemistry
UEA Research Groups: Faculty of Science > Research Groups > Chemistry of Materials and Catalysis
Faculty of Science > Research Groups > Chemistry of Life Processes
Faculty of Science > Research Centres > Centre for Molecular and Structural Biochemistry
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Depositing User: LivePure Connector
Date Deposited: 30 Jan 2020 04:15
Last Modified: 29 Jun 2023 12:30
DOI: 10.1246/cl.190179

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