Increasing anti-cancer activity with longer tether lengths of group 9 Cp∗ complexes

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Lucas, Stephanie J., Lord, Rianne M. ORCID: https://orcid.org/0000-0001-9981-129X, Basri, Aida M., Allison, Simon J., Phillips, Roger M., Blacker, A. John and McGowan, Patrick C. (2016) Increasing anti-cancer activity with longer tether lengths of group 9 Cp∗ complexes. Dalton Transactions, 45 (16). pp. 6812-6815. ISSN 1477-9226

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Abstract

Here in, we report the cytotoxicity of both rhodium and iridium functionalised Cp* analogues of the [Cp*MCl2]2 dimers. The functionalised dimers contain a hydroxy tethered arm of differing carbon length. These show promising IC50 values when tested against HT-29, A2780 and cisplatin-resistant A2780cis human cancer cell lines, with the cytotoxicity improving proportionally with an increase in carbon tether length of the Cp* ring. The most promising results are seen for the 14-carbon Cp* tethered rhodium (2d) and iridium (3b) complexes, which show up to a 24-fold increase in IC50 compared to the unfunctionalised [Cp*MCl2]2 dimer. All complexes were potent inhibitors of purified thioredoxin reductase suggesting that disruption of cellular anti-oxidant function is one potential mechanism of action.

Item Type: Article
Uncontrolled Keywords: sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School: Faculty of Science > School of Chemistry
UEA Research Groups: Faculty of Science > Research Groups > Chemistry of Materials and Catalysis
Faculty of Science > Research Groups > Chemistry of Life Processes
Faculty of Science > Research Centres > Centre for Molecular and Structural Biochemistry
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Depositing User: LivePure Connector
Date Deposited: 30 Jan 2020 04:15
Last Modified: 22 Oct 2022 05:46
URI: https://ueaeprints.uea.ac.uk/id/eprint/73874
DOI: 10.1039/c6dt00186f

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