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Ardona, Herdeline, Draper, Emily, Wallace, Matthew 
ORCID: https://orcid.org/0000-0002-5751-1827, Citossi, Francesca, Serpell, Louise, Adams, Dave J. and Tovar, John D.
(2017)
Kinetically controlled coassembly of multichromophoric peptide hydrogelators and the impacts on energy transport.
Journal of the American Chemical Society, 139 (25).
pp. 8685-8692.
ISSN 0002-7863
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Abstract
We report a peptide-based multichromophoric hydrogelator system, wherein π-electron units with different inherent spectral energies are spatially controlled within peptidic 1-D nanostructures to create localized energy gradients in aqueous environments. This is accomplished by mixing different π-conjugated peptides prior to initiating self-assembly through solution acidification. We can vary the kinetics of the assembly and the degree of self-sorting through the choice of the assembly trigger, which changes the kinetics of acidification. The hydrolysis of glucono-'lactone (GdL) provides a slow pH drop that allows for stepwise triggering of peptide components into essentially self-sorted nanostructures based on subtle pKa differences, whereas HCl addition leads to a rapid formation of mixed components within a nanostructure. Using 1H NMR spectroscopy and fiber X-ray diffraction, we determine the conditions and peptide mixtures that favor self-sorting or intimate comixing. Photophysical investigations in the solution phase provide insight into the correlation of energy-transport processes occurring within the assemblies to the structural organization of the π-systems.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | nanostructures,supramolecular structures and assemblies,peptides and proteins,absorption,hydrogels |
| Faculty \ School: | Faculty of Science > School of Pharmacy |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 21 Jan 2020 03:15 |
| Last Modified: | 22 Oct 2022 05:43 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/73697 |
| DOI: | 10.1021/jacs.7b04006 |
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