Ardona, Herdeline, Draper, Emily, Wallace, Matthew, Citossi, Francesca, Serpell, Louise, Adams, Dave J. and Tovar, John D. (2017) Kinetically controlled coassembly of multichromophoric peptide hydrogelators and the impacts on energy transport. Journal of the American Chemical Society, 139 (25). pp. 8685-8692. ISSN 0002-7863

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Abstract

We report a peptide-based multichromophoric hydrogelator system, wherein π-electron units with different inherent spectral energies are spatially controlled within peptidic 1-D nanostructures to create localized energy gradients in aqueous environments. This is accomplished by mixing different π-conjugated peptides prior to initiating self-assembly through solution acidification. We can vary the kinetics of the assembly and the degree of self-sorting through the choice of the assembly trigger, which changes the kinetics of acidification. The hydrolysis of glucono-'lactone (GdL) provides a slow pH drop that allows for stepwise triggering of peptide components into essentially self-sorted nanostructures based on subtle pKa differences, whereas HCl addition leads to a rapid formation of mixed components within a nanostructure. Using 1H NMR spectroscopy and fiber X-ray diffraction, we determine the conditions and peptide mixtures that favor self-sorting or intimate comixing. Photophysical investigations in the solution phase provide insight into the correlation of energy-transport processes occurring within the assemblies to the structural organization of the π-systems.

Item Type:	Article
Uncontrolled Keywords:	nanostructures,supramolecular structures and assemblies,peptides and proteins,absorption,hydrogels
Faculty \ School:	Faculty of Science > School of Pharmacy
Related URLs:	https://livrepository.liverpool.ac.uk/30...
Depositing User:	LivePure Connector
Date Deposited:	21 Jan 2020 03:15
Last Modified:	21 Jul 2021 01:28
URI:	https://ueaeprints.uea.ac.uk/id/eprint/73697
DOI:	10.1021/jacs.7b04006

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