Metabolomics analysis in adults with High Bone Mass identifies a relationship between bone resorption and circulating citrate which replicates in the general population

Hartley, April, Paternoster, Lavinia, Evans, David M., Fraser, William, Tang, Jonathan C Y, Lawlor, Debbie A., Tobias, Jon H. and Gregson, Celia L. (2020) Metabolomics analysis in adults with High Bone Mass identifies a relationship between bone resorption and circulating citrate which replicates in the general population. Clinical Endocrinology, 92 (1). pp. 29-37. ISSN 0300-0664

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Abstract

Objective: Bone turnover, which regulates bone mass, may exert metabolic consequences, particularly on markers of glucose metabolism and adiposity. To better understand these relationships, we examined cross-sectional associations between bone turnover markers (BTMs) and metabolic traits in a population with high bone mass (HBM, BMD Z-score>+3.2). Design: β-C-terminal telopeptide of type-I collagen (β-CTX), procollagen type-1 amino-terminal propeptide (P1NP) and osteocalcin were assessed by electrochemiluminescence immunoassays. Metabolic traits, including lipids and glycolysis-related metabolites, were measured using Nuclear Magnetic Resonance spectroscopy. Associations of BTMs with metabolic traits were assessed using Generalized Estimating Equation linear regression, accounting for within-family correlation, adjusting for potential confounders (age, sex, height, weight, menopause, bisphosphonate and oral glucocorticoid use). Results: 198 adults with HBM had complete data, mean [SD] age 61.6 [13.7] years; 77% female. Of 23 summary metabolic traits, citrate was positively related to all BTMs: adjusted ββ-CTX=0.050 (95% CI 0.024,0.076),p=1.71x10-4, βosteocalcin=6.54x10-4 (1.87x10-4,0.001),p=0.006 and βP1NP=2.40x10-4 (6.49x10-5,4.14x10-4),p=0.007 (β= increase in citrate (mmol/L) per 1μg/L BTM increase). Inverse relationships of β-CTX (β=-0.276 -0.434,-0.118],p=6.03x10-4) and osteocalcin (-0.004 [-0.007,-0.001],p=0.020) with triglycerides were also identified. We explored the generalizability of these associations in 3,664 perimenopausal women (age 47.9 [4.4] years) from a UK family cohort. We confirmed a positive, albeit lower magnitude, association between β-CTX and citrate (adjusted βwomen=0.020 [0.013,0.026],p=1.95x10-9) and an inverse association of similar magnitude between β-CTX and triglycerides (β=-0.354 [-0.471,-0.237],p=3.03x10-9). Conclusions: Bone resorption is positively related to circulating citrate and inversely related to triglycerides. Further studies are justified to determine whether plasma citrate or triglyceride concentrations are altered by factors known to modulate bone resorption, such as bisphosphonates.

Item Type: Article
Additional Information: © 2019 The Authors. Clinical Endocrinology published by John Wiley & Sons Ltd.
Uncontrolled Keywords: bone turnover,metabolomics,high bone mass,citrate,alspac,triglycerides,triglycerides,turnover,biochemical markers,sensitivity,pubertal changes,biomarkers,individuals,magnetic-resonance metabolomics,osteocalcin,epidemiology,fat mass,endocrinology,endocrinology, diabetes and metabolism ,/dk/atira/pure/subjectarea/asjc/1300/1310
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
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Depositing User: LivePure Connector
Date Deposited: 21 Jan 2020 03:09
Last Modified: 26 Jul 2020 23:47
URI: https://ueaeprints.uea.ac.uk/id/eprint/73691
DOI: 10.1111/cen.14119

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