Origin of OXA-23 variant OXA-239 from a recently emerged lineage of Acinetobacter baumannii International Clone V

Grana-Miraglia, Lucia, Evans, Ben, Lopez Jacome, Luis, Hernández-Durán, Melissa, Colín-Castro, Claudia, Volkow-Fernández, Patricia, Cevallos, Miguel, Franco-Cendejas, Rafael and Castillo-Ramirez, Santiago (2020) Origin of OXA-23 variant OXA-239 from a recently emerged lineage of Acinetobacter baumannii International Clone V. mSphere, 5 (1). ISSN 2379-5042

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Abstract

Over the last few decades, carbapenemase-producing Acinetobacter baumannii has become a major cause of nosocomial infections all over the world. However, the genome identity of lineages of this species in Latin America has not been studied as much as in developed countries. Here, through a population genomics approach considering the whole genomes of 148 isolates (almost 40 from Mexico and Honduras), we describe the recent emergence of the lineage sequence type 758 (ST758), which belongs to the international clone V and has spread out to Canada, Mexico, Honduras, and Colombia. Notably, this lineage was found to coexist with other A. baumannii lineages in hospitals in Mexico and Honduras. Isolates from this lineage show considerable variation in antibiotic resistance profiles, but most of them are resistant to carbapenems. Moreover, we found a variety of acquired oxacillinase (OXA) families within this lineage and tracked the very recent inception, and subsequent horizontal transmission, of the OXA-239 carbapenemase. This work highlights the urgent need to investigate recently emerged lineages of this species in Latin America and elsewhere, as these might harbor novel antibiotic resistance genes.

Item Type: Article
Additional Information: Copyright © 2020 Graña-Miraglia et al.
Uncontrolled Keywords: acinetobacter baumannii,evolution,global spread,hospitals,ic5,oxa,oxa beta-lactamases,oxa-239,tool,evolutionary biology,genome analysis,infectious diseases,international clones,molecular epidemiology,population genomics
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
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Depositing User: LivePure Connector
Date Deposited: 10 Jan 2020 04:24
Last Modified: 05 Aug 2020 23:46
URI: https://ueaeprints.uea.ac.uk/id/eprint/73581
DOI: 10.1128/mSphere.00801-19

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