Distinguishing frontotemporal dementia from Alzheimer disease through everyday function profiles: Trajectories of change

Giebel, Clarissa M., Knopman, David, Mioshi, Eneida and Khondoker, Mizanur ORCID: https://orcid.org/0000-0002-1801-1635 (2021) Distinguishing frontotemporal dementia from Alzheimer disease through everyday function profiles: Trajectories of change. Journal of Geriatric Psychiatry and Neurology, 34 (1). pp. 66-75. ISSN 0891-9887

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Background: Different dementia syndromes display different patterns of everyday functioning. This article explored different patterns of functioning at baseline and trajectories of change in behavioral variant frontotemporal dementia (bvFTD) and Alzheimer disease (AD). Methods: Data from the Uniform Data Set of the National Alzheimer’s Coordinating Centre were employed. The Functional Assessment Questionnaire assessed functioning at up to 7 follow-up visits. Independent t tests assessed variations in functioning between syndromes at baseline. Linear mixed-effect modeling explored longitudinal functional trajectories between syndromes. Results: Data from 3351 patients (306 bvFTD and 3,045AD) were analyzed. At baseline, patients with bvFTD performed all daily activities poorer than AD dementia. Linear mixed models showed a significant effect of syndrome and time on functioning, and evidence of interaction between syndrome and time, with bvFTD showing a steeper decline for using the stove and travel. Conclusions: Findings can help in the effective care planning of everyday functioning for bvFTD and AD dementia.

Item Type: Article
Uncontrolled Keywords: activities of daily living,alzheimer disease,frontotemporal dementia,mini-mental-state,instrumental activities,performance,memory profiles,symptoms,mild cognitive impairment,decline,behavioral-variant,abilities,quality-of-life,clinical neurology,geriatrics and gerontology,psychiatry and mental health,sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/2700/2728
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Faculty of Medicine and Health Sciences > School of Health Sciences
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Depositing User: LivePure Connector
Date Deposited: 03 Jan 2020 04:01
Last Modified: 21 Apr 2023 00:18
URI: https://ueaeprints.uea.ac.uk/id/eprint/73461
DOI: 10.1177/0891988720901791

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