The chicken as a model organism to study heart development:Cold Spring Harbor Perspective in Biology

Wittig, Johannes and Munsterberg, Andrea ORCID: (2020) The chicken as a model organism to study heart development:Cold Spring Harbor Perspective in Biology. In: Cold Spring Harbor Perspectives in Biology. Cold Spring Harbor Laboratory Press, pp. 1-17.

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Heart development is a complex process and begins with the long-range migration of cardiac progenitor cells during gastrulation. This culminates in the formation of a simple contractile tube with multiple layers, which undergoes remodeling into a four-chambered heart. During this morphogenesis additional cell populations become incorporated. It is important to unravel the underlying genetic and cellular mechanisms to be able to identify the embryonic origin of diseases, including congenital malformations, which impair cardiac function and may affect life expectancy or quality. Owing to the evolutionary conservation of development, observations made in non-amniote and amniote vertebrate species allow us to extrapolate to human. This review will focus on the contributions made to a better understanding of heart development through studying avian embryos – mainly the chicken but also quail embryos. We will illustrate the classic and recent approaches used in the avian system, give an overview of the important discoveries made and summarize the early stages of cardiac development up to the establishment of the four chambered heart.

Item Type: Book Section
Additional Information: Funding Information: J.G.W. was funded by a studentship from the British Heart Foundation (BHF FS/15/41/31 564). Research in A.M.’s laboratory was supported by a BHF Project Grant (PG/15/77/3176). Publisher Copyright: © 2020 Cold Spring Harbor Laboratory Press; all rights reserved;.
Uncontrolled Keywords: biochemistry, genetics and molecular biology(all),sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/1300
Faculty \ School: Faculty of Science > School of Biological Sciences
UEA Research Groups: Faculty of Science > Research Groups > Cells and Tissues
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Depositing User: LivePure Connector
Date Deposited: 05 Dec 2019 02:32
Last Modified: 21 Apr 2023 01:45
DOI: 10.1101/cshperspect.a037218


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