Recent progress in the development of small-molecule FtsZ inhibitors as chemical tools for the development of novel antibiotics

Carro, Laura (2019) Recent progress in the development of small-molecule FtsZ inhibitors as chemical tools for the development of novel antibiotics. Antibiotics, 8 (4). ISSN 2079-6382

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Abstract

Antibiotics are potent pharmacological weapons against bacterial pathogens, nevertheless their efficacy is becoming compromised due to the worldwide emergence and spread of multidrug-resistant bacteria or "superbugs". Antibiotic resistance is rising to such dangerous levels that the treatment of bacterial infections is becoming a clinical challenge. Therefore, urgent action is needed to develop new generations of antibiotics that will help tackle this increasing and serious public health problem. Due to its essential role in bacterial cell division, the tubulin-like protein FtsZ has emerged as a promising target for the development of novel antibiotics with new mechanisms of action. This review highlights the medicinal chemistry efforts towards the identification of small-molecule FtsZ inhibitors with antibacterial activity in the last three years.

Item Type: Article
Additional Information: Funding information: L.C. thanks the Spanish Junta de Castilla y León and the European Regional Development Fund for a post-doctoral contract (reference SA262P18).
Uncontrolled Keywords: sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School: Faculty of Science > School of Pharmacy
UEA Research Groups: Faculty of Science > Research Groups > Chemical Biology and Medicinal Chemistry (former - to 2021)
Depositing User: LivePure Connector
Date Deposited: 27 Nov 2019 02:01
Last Modified: 20 Apr 2023 11:30
URI: https://ueaeprints.uea.ac.uk/id/eprint/73123
DOI: 10.3390/antibiotics8040217

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