Cardiovascular involvement in primary systemic vasculitis

Mukhtyar, Chetan, Brogan, Paul and Luqmani, Raashid (2009) Cardiovascular involvement in primary systemic vasculitis. Best Practice & Research: Clinical Rheumatology, 23 (3). pp. 419-428. ISSN 1521-6942

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Abstract

The primary systemic vasculitides are a group of autoimmune conditions characterised by occlusion, stenosis or aneurysmal dilatation of blood vessels secondary to intra-mural inflammation. Current therapy has converted the outlook of these diseases from death or severe morbidity to a remitting-relapsing condition in most instances. Longer survival, relapsing course of disease and chronic glucocorticoid therapy probably contribute to an increase in cardiovascular events and morbidity. This article reviews the available data for effect of primary systemic vasculitis on cardiovascular end points like coronary artery disease, congestive cardiac failure, hypertension and aortic aneurysm in all age groups. We examine the interplay between the activated endothelium, autoimmune mechanisms and treatment factors to produce a direct insult or increased atherogenic potential of primary systemic vasculitis. Recommendations to deal with cardiovascular end points are made.

Item Type: Article
Uncontrolled Keywords: adolescent,complications,complications,child,child, preschool,complications,female,complications,humans,complications,male,survival rate,complications,young adult
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: LivePure Connector
Date Deposited: 27 Nov 2019 02:00
Last Modified: 22 Apr 2020 08:23
URI: https://ueaeprints.uea.ac.uk/id/eprint/73102
DOI: 10.1016/j.berh.2009.02.002

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