A cross-sectional study of the Birmingham Vasculitis Activity Score version 3 in systemic vasculitis

Suppiah, Ravi, Mukhtyar, Chetan, Flossmann, Oliver, Alberici, Federico, Baslund, Bo, Batra, Rajbir, Brown, Denise, Holle, Julia, Hruskova, Zdenka, Jayne, David R W, Judge, Andrew, Little, Mark A, Palmisano, Alessandra, Stegeman, Coen, Tesar, Vladimir, Vaglio, Augusto, Westman, Kerstin and Luqmani, Raashid (2011) A cross-sectional study of the Birmingham Vasculitis Activity Score version 3 in systemic vasculitis. Rheumatology, 50 (5). pp. 899-905. ISSN 1462-0324

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Abstract

OBJECTIVE: Assessment of disease activity in vasculitis can be achieved using the BVAS, a clinical checklist of relevant symptoms, signs and features of active disease. The aim of this study was to revalidate the BVAS version 3 (BVAS v. 3) in a cohort of patients with systemic vasculitis. METHODS: A total of 238 patients with vasculitis from seven countries in Europe were evaluated at a single time point. Spearman's correlation coefficients were calculated between BVAS v. 3 scores, vasculitis activity index (VAI), physician's global assessment (PGA), the physician's treatment decision, CRP and the vasculitis damage index (VDI) to demonstrate that the BVAS v. 3 measures disease activity. RESULTS: WG (63%), Churg-Strauss syndrome (9%) and microscopic polyangiitis (9%) were the most common diagnoses. The BVAS v. 3 showed convergent validity with the VAI [ρ = 0.82 (95% CI 0.77, 0.85)], PGA [ρ = 0.85 (95% CI 0.81, 0.88)] and the physician's treatment decision [ρ = 0.54 (95% CI 0.44, 0.62)]. There was little or no correlation between BVAS v. 3 and the CRP level [ρ = 0.18 (95% CI 0.05, 0.30)] or with the VDI [ρ = -0.10 (95% CI 0.22, 0.03)]. The inter-observer reliability was very high with an intra-class correlation coefficient (ICC) of 0.996 (95% CI 0.990, 0.998) for the total BVAS v. 3 score. CONCLUSION: The BVAS v. 3 has been evaluated in a large cohort of patients with vasculitis and the important properties of the tool revalidated. This study increases the utility of the BVAS v. 3 in different populations of patients with systemic vasculitis.

Item Type: Article
Uncontrolled Keywords: adolescent,adult,aged,aged, 80 and over,diagnosis,cohort studies,cross-sectional studies,epidemiology,female,diagnosis,humans,male,diagnosis,middle aged,observer variation,reproducibility of results,severity of illness index,classification,young adult
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: LivePure Connector
Date Deposited: 27 Nov 2019 02:00
Last Modified: 22 Apr 2020 08:23
URI: https://ueaeprints.uea.ac.uk/id/eprint/73099
DOI: 10.1093/rheumatology/keq400

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