Behçet's pulmonary artery aneurysms treated with infliximab and monitored with the 6-min walk test

Kotecha, Jalpa, Kamath, Ajay V and Mukhtyar, Chetan (2016) Behçet's pulmonary artery aneurysms treated with infliximab and monitored with the 6-min walk test. Oxford Medical Case Reports, 2016 (4). pp. 94-6. ISSN 2053-8855

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Abstract

Pulmonary involvement in Behçet's disease (BD) is uncommon; however, it is potentially fatal due to the risk of massive haemoptysis. We describe the case of a 36-year-old male presenting with a 2-month history of worsening dyspnoea, weight loss, haemoptysis, oral ulceration, erythema nodosum and superficial thrombophlebitis. He was diagnosed with pulmonary vasculitis secondary to BD; however, his symptoms were refractory to initial treatment with cyclophosphamide, azathioprine and prednisolone. We therefore trialled infliximab alongside methotrexate, which led to a remarkable improvement in his condition, enabling eventual discontinuation of prednisolone. Whilst not being one of the treatments currently recommended for managing pulmonary involvement in BD, infliximab has previously been successfully used in cases refractory to conventional therapy. We used the 6-min walk test (distance covered and lowest oxygen saturations) to monitor his progress, which correlated with his symptoms. This may represent a useful adjunct in monitoring the activity of pulmonary vasculitis.

Item Type: Article
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: LivePure Connector
Date Deposited: 27 Nov 2019 02:00
Last Modified: 20 Aug 2020 00:59
URI: https://ueaeprints.uea.ac.uk/id/eprint/73094
DOI: 10.1093/omcr/omw028

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