Mitochondrial dysfunction is the cause of one of the earliest changes seen on magnetic resonance imaging in Charcot neuroarthopathy – Oedema of the small muscles in the foot

Lymbouris, Margarita, Gooday, Catherine and Dhatariya, Ketan K. (2020) Mitochondrial dysfunction is the cause of one of the earliest changes seen on magnetic resonance imaging in Charcot neuroarthopathy – Oedema of the small muscles in the foot. Medical Hypotheses, 134. ISSN 0306-9877

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Abstract

The hypothesis laid out in this thesis states that the early changes seen on an MR imaging in those with early Charcot neuroarthopathy may be due to mitochondrial dysfunction. In a Charcot foot, there is movement between bones. In an attempt to prevent this movement, the small muscles of the foot contract continuously when the foot is weight bearing. This contraction takes energy in the form of ATP. However, the reduction of glucose transport into the muscle cells due to insulin resistance / insufficiency, leads to reduction in the ATP producing capacity of the mitochondria. The ATP depletion affects the cell membrane gradient leading to mitochondrial and cellular swelling. These early cellular changes could then be picked up with MR imaging as muscle oedema.

Item Type: Article
Uncontrolled Keywords: charcot neuroarthropathy,disease,exercise,high insulin,human skeletal-muscle,mechanisms,mitochondria,muscle oedema,protein-synthesis
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Faculty of Medicine and Health Sciences > School of Health Sciences
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Depositing User: LivePure Connector
Date Deposited: 25 Oct 2019 15:30
Last Modified: 18 Oct 2020 00:40
URI: https://ueaeprints.uea.ac.uk/id/eprint/72789
DOI: 10.1016/j.mehy.2019.109439

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