Disinhibition in Frontotemporal Dementia and Alzheimer's Disease:A Neuropsychological and Behavioural Investigation

Mariano, Luciano I, O'Callaghan, Claire, Guimarães, Henrique C, Gambogi, Leandro B, da Silva, Thaís B L, Yassuda, Mônica S, Amaral, Juliana S, Caramelli, Paulo, Hornberger, Michael, Teixeira, Antônio L and de Souza, Leonardo C (2020) Disinhibition in Frontotemporal Dementia and Alzheimer's Disease:A Neuropsychological and Behavioural Investigation. Journal of the International Neuropsychological Society, 26 (2). pp. 163-171. ISSN 1355-6177

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Abstract

OBJECTIVE: Cognitive tests of inhibitory control show variable results for the differential diagnosis between behavioural variant of Frontotemporal Dementia (bvFTD) and Alzheimer's disease (AD). We compared the diagnostic accuracies of tests of inhibitory control and of a behavioural questionnaire, to distinguish bvFTD from AD. METHODS: Three groups of participants were enrolled: 27 bvFTD patients, 25 AD patients, and 24 healthy controls. Groups were matched for gender, education, and socio-economic level. Participants underwent a comprehensive neuropsychological assessment of inhibitory control, including Hayling Test, Stroop, the Five Digits Test (FDT) and the Delay Discounting Task (DDT). Caregivers completed the Barratt Impulsiveness Scale 11th version (BIS-11). RESULTS: bvFTD and AD groups showed no difference in the tasks of inhibitory control, while the caregiver questionnaire revealed that bvFTD patients were significantly more impulsive (BIS-11: bvFTD 76.1+9.5, AD 62.9+13, p < .001). CONCLUSIONS: Neuropsychological tests of inhibitory control failed to distinguish bvFTD from AD. On the contrary, impulsivity caregiver-completed questionnaire provided good distinction between bvFTD and AD. These results highlight the current limits of cognitive measures of inhibitory control for the differential diagnosis between bvFTD and AD, whereas questionnaire information appears more reliable and in line with clinical diagnostics.

Item Type: Article
Uncontrolled Keywords: alzheimer's disease,behavioural variant frontotemporal dementia,delay discounting,executive function,impulsivity,inhibitory control,battery,apathy,rewards,memory profiles,impulsivity,variant,inventory,inhibitory dysfunction,diagnostic-criteria,clinical neurology,psychiatry and mental health,clinical psychology,neuroscience(all) ,/dk/atira/pure/subjectarea/asjc/2700/2728
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
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Depositing User: LivePure Connector
Date Deposited: 22 Oct 2019 11:33
Last Modified: 29 May 2020 00:18
URI: https://ueaeprints.uea.ac.uk/id/eprint/72742
DOI: 10.1017/S1355617719000973

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