Mechanical properties of Triclosan sutures

Jungwirth-Weinberger, Anna, Grubhofer, Florian, Imam, Mohamed A, Bachmann, Elias and Wirth, Stephan (2018) Mechanical properties of Triclosan sutures. Journal of Orthopaedic Research, 36 (6). pp. 1777-1782. ISSN 0736-0266

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Abstract

To avoid infections and wound healing disorders, Triclosan coated sutures have been invented. Little is known of these sutures regarding their tensile properties. Three different Triclosan coated sutures (Vicryl 1 plus, PDS 0 plus, Monocryl 3-0 plus) were tested at several time points over 42 days regarding load to failure, strain, and stiffness compared to their non-coated versions (Vicryl 1, PDS 0, Monocryl 3-0). Four different measurement points were made. Suture loops were fixed in a material testing machine over two metal bars which were moved apart creating a stress to the fiber. Unpaired, two-tailed t-test were performed for each group (untreated and treated) while level of significance was defined at a level of p < 0.05. Vicryl 1 was significantly stronger on day 14 than Vicryl 1 plus (p = 0.033). On day 28, significant changes were found in PDS 0 which was weaker compared to PDS 0 plus (p = 0.039) and Vicryl 1 which was stronger than Vicryl 1 plus (p = 0.032). We have seen that Vicryl 1 plus sutures are significantly weaker according to loading to failure after 14 and 28 days, which might cause incisional hernias. PDS 0 sutures are used to reconstruct tendons, therefore a longer durableness might be of interest as re-ruptures of tendons are problematic. Our in vitro findings support, the use of Triclosan coated PDS plus sutures and Vicryl sutures as they show a longer resistance. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:1777-1782, 2018.

Item Type: Article
Additional Information: © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.
Uncontrolled Keywords: biomechanical phenomena,materials testing,polyglactin 910,prevention & control,sutures,tensile strength,triclosan,wound healing
Depositing User: LivePure Connector
Date Deposited: 17 Oct 2019 13:32
Last Modified: 22 Apr 2020 08:02
URI: https://ueaeprints.uea.ac.uk/id/eprint/72664
DOI: 10.1002/jor.23814

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