Multidisciplinary rehabilitation reduces hypothalamic grey matter volume loss in individuals with preclinical Huntington's disease: A nine-month pilot study

Bartlett, Danielle M., Dominguez D, Juan F., Lazar, Alpar S., Kordsachia, Catarina C., Rankin, Tim J., Lo, Johnny, Govus, Andrew D., Power, Brian D., Lampit, Amit, Eastwood, Peter R., Ziman, Mel R. and Cruickshank, Travis M. (2020) Multidisciplinary rehabilitation reduces hypothalamic grey matter volume loss in individuals with preclinical Huntington's disease: A nine-month pilot study. Journal of the Neurological Sciences, 408. ISSN 0022-510X

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Abstract

Background Hypothalamic pathology is a well-documented feature of Huntington's disease (HD) and is believed to contribute to circadian rhythm and habitual sleep disturbances. Currently, no therapies exist to combat hypothalamic changes, nor circadian rhythm and habitual sleep disturbances in HD. Objective To evaluate the effects of multidisciplinary rehabilitation on hypothalamic volume, brain-derived neurotrophic factor (BDNF), circadian rhythm and habitual sleep in individuals with preclinical HD. Methods Eighteen individuals with HD (ten premanifest and eight prodromal) undertook a nine-month multidisciplinary rehabilitation intervention (intervention group), which included exercise, cognitive and dual task training and social events, and were compared to a community sample of eleven individuals with premanifest HD receiving no intervention (control group). Hypothalamic volume, serum BDNF, salivary cortisol and melatonin concentrations, subjective sleep quality, daytime somnolence, habitual sleep-wake patterns, stress and anxiety and depression symptomatology were evaluated. Results Hypothalamus grey matter volume loss was significantly attenuated in the intervention group compared to the control group after controlling for age, gender, Unified Huntington's Disease Rating Scale-Total Motor Score and number of cytosine-adenine-guanine repeats. Serum BDNF levels were maintained in the intervention group, but decreased in the control group following the study period. Both groups exhibited decreases in cortisol and melatonin concentrations. No changes were observed in sleep or mood outcomes. Conclusions This exploratory study provides evidence that multidisciplinary rehabilitation can reduce hypothalamic volume loss and maintain peripheral BDNF levels in individuals with preclinical HD but may not impact on circadian rhythm. Larger, randomised controlled trials are required to confirm these findings.

Item Type: Article
Uncontrolled Keywords: brain-derived neurotrophic factor,circadian rhythm,cortisol,deficits,environmental enrichment,exercise,hypothalamus,melatonin,melatonin,neurogenesis,neurotrophic factor bdnf,parkinsons,periodization,sleep-wake cycle,sleep,transgenic mouse model
Faculty \ School: Faculty of Medicine and Health Sciences > School of Health Sciences
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Depositing User: LivePure Connector
Date Deposited: 15 Oct 2019 10:30
Last Modified: 31 May 2020 23:49
URI: https://ueaeprints.uea.ac.uk/id/eprint/72589
DOI: 10.1016/j.jns.2019.116522

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