Guiding therapy by coronary CT angiography improves outcomes in patients with stable chest pain

Adamson, Philip D., Williams, Michelle C., Dweck, Marc R., Mills, Nicholas L., Boon, Nicholas A., Daghem, Marwa, Bing, Rong, Moss, Alastair J., Mangion, Kenneth, Flather, Marcus, Forbes, John, Hunter, Amanda, Norrie, John, Shah, Anoop S. V., Timmis, Adam D., Van Beek, Edwin J.r., Ahmadi, Amir A., Leipsic, Jonathon, Narula, Jagat, Newby, David E., Roditi, Giles, Mcallister, David A. and Berry, Colin (2019) Guiding therapy by coronary CT angiography improves outcomes in patients with stable chest pain. Journal of the American College of Cardiology, 74 (16). pp. 2058-2070. ISSN 0735-1097

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Background Within the SCOT-HEART (Scottish COmputed Tomography of the HEART Trial) trial of patients with stable chest pain, the use of coronary computed tomography angiography (CTA) reduced the rate of death from coronary heart disease or nonfatal myocardial infarction (primary endpoint). Objectives This study sought to assess the consistency and mechanisms of the 5-year reduction in this endpoint. Methods In this open-label trial, 4,146 participants were randomized to standard care alone or standard care plus coronary CTA. This study explored the primary endpoint by symptoms, diagnosis, coronary revascularizations, and preventative therapies. Results Event reductions were consistent across symptom and risk categories (p = NS for interactions). In patients who were not diagnosed with angina due to coronary heart disease, coronary CTA was associated with a lower primary endpoint incidence rate (0.23; 95% confidence interval [CI]: 0.13 to 0.35 vs. 0.59; 95% CI: 0.42 to 0.80 per 100 patient-years; p < 0.001). In those who had undergone coronary CTA, rates of coronary revascularization were higher in the first year (hazard ratio [HR]: 1.21; 95% CI: 1.01 to 1.46; p = 0.042) but lower beyond 1 year (HR: 0.59; 95% CI: 0.38 to 0.90; p = 0.015). Patients assigned to coronary CTA had higher rates of preventative therapies throughout follow-up (p < 0.001 for all), with rates highest in those with CT-defined coronary artery disease. Modeling studies demonstrated the plausibility of the observed effect size. Conclusions The beneficial effect of coronary CTA on outcomes is consistent across subgroups with plausible underlying mechanisms. Coronary CTA improves coronary heart disease outcomes by enabling better targeting of preventative treatments to those with coronary artery disease. (Scottish COmputed Tomography of the HEART Trial [SCOT-HEART]; NCT01149590)

Item Type: Article
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups: Faculty of Medicine and Health Sciences > Research Groups > Cardiovascular and Metabolic Health
Faculty of Medicine and Health Sciences > Research Groups > Norwich Clinical Trials Unit
Faculty of Medicine and Health Sciences > Research Groups > Public Health and Health Services Research (former - to 2023)
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Depositing User: LivePure Connector
Date Deposited: 15 Oct 2019 10:30
Last Modified: 22 Oct 2022 05:21
DOI: 10.1016/j.jacc.2019.07.085


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