Maintaining integrity under stress: Envelope stress response regulation of pathogenesis in gram-negative bacteria

Hews, Claire L., Cho, Timothy, Rowley, Gary and Raivio, Tracy L. (2019) Maintaining integrity under stress: Envelope stress response regulation of pathogenesis in gram-negative bacteria. Frontiers in Cellular and Infection Microbiology, 9. ISSN 2235-2988

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Abstract

The Gram-negative bacterial envelope is an essential interface between the intracellular and harsh extracellular environment. Envelope stress responses (ESRs) are crucial to the maintenance of this barrier and function to detect and respond to perturbations in the envelope, caused by environmental stresses. Pathogenic bacteria are exposed to an array of challenging and stressful conditions during their lifecycle and, in particular, during infection of a host. As such, maintenance of envelope homeostasis is essential to their ability to successfully cause infection. This review will discuss our current understanding of the σE- and Cpx-regulated ESRs, with a specific focus on their role in the virulence of a number of model pathogens.

Item Type:	Article
Additional Information:	Funding information: This work was funded by operating grant MOP 342982 from the Canadian Institutes of Health Research and discovery grant RGPIN 238422-2013 from the Natural Sciences and Engineering Research Council to TR and a Norwich Research Park BBSRC Doctoral Training Partnership Studentship awarded to CH (BB/M011216/1).
Faculty \ School:	Faculty of Science > School of Biological Sciences
UEA Research Groups:	Faculty of Science > Research Groups > Molecular Microbiology
Depositing User:	LivePure Connector
Date Deposited:	01 Oct 2019 14:30
Last Modified:	03 Aug 2023 11:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/72432
DOI:	10.3389/fcimb.2019.00313

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