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ToolsHews, Claire L., Cho, Timothy, Rowley, Gary and Raivio, Tracy L. (2019) Maintaining integrity under stress: Envelope stress response regulation of pathogenesis in gram-negative bacteria. Frontiers in Cellular and Infection Microbiology, 9. ISSN 2235-2988
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Abstract
The Gram-negative bacterial envelope is an essential interface between the intracellular and harsh extracellular environment. Envelope stress responses (ESRs) are crucial to the maintenance of this barrier and function to detect and respond to perturbations in the envelope, caused by environmental stresses. Pathogenic bacteria are exposed to an array of challenging and stressful conditions during their lifecycle and, in particular, during infection of a host. As such, maintenance of envelope homeostasis is essential to their ability to successfully cause infection. This review will discuss our current understanding of the σE- and Cpx-regulated ESRs, with a specific focus on their role in the virulence of a number of model pathogens.
| Item Type: | Article |
|---|---|
| Additional Information: | Funding information: This work was funded by operating grant MOP 342982 from the Canadian Institutes of Health Research and discovery grant RGPIN 238422-2013 from the Natural Sciences and Engineering Research Council to TR and a Norwich Research Park BBSRC Doctoral Training Partnership Studentship awarded to CH (BB/M011216/1). |
| Faculty \ School: | Faculty of Science > School of Biological Sciences |
| UEA Research Groups: | Faculty of Science > Research Groups > Molecular Microbiology Faculty of Medicine and Health Sciences > Research Groups > Pathogen Biology Group |
| Depositing User: | LivePure Connector |
| Date Deposited: | 01 Oct 2019 14:30 |
| Last Modified: | 17 Jul 2025 14:34 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/72432 |
| DOI: | 10.3389/fcimb.2019.00313 |
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