Synthesis, crystal structure, and cytotoxicity studies of titanacalix[4 and 8]arene complexes

Miller-Shakesby, David M., Nigam, Shubhanchi, Hughes, David L., Lopez-Estelles, Enrique, Elsegood, Mark R.J., Cawthorne, Christopher J., Archibald, Stephen J. and Redshaw, Carl (2018) Synthesis, crystal structure, and cytotoxicity studies of titanacalix[4 and 8]arene complexes. Dalton Transactions, 47 (27). pp. 8992-8999. ISSN 1477-9226

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Abstract

Reaction of 5,11,17,23-tetra-tert-butyl-dihydroxy-26,28-bis(2-pentoxy)calix[4]arene (L(OH)2(Opentyl)2) with [TiCl4] afforded the dichlorotitanoacalix[4]arene complex [TiCl2L(O)2(Opentyl)2] (1) in good yield. Hydrolysis of 1 led to the isolation of the complex {[TiL(O)3(Opentyl)]2(μ-OH)(μ-Cl)} (2). Reaction of 5,11,17,23,29,35,41,47-p-tert-butyl-49,50,51,52,53,54,55,56-octapropoxycalix[8]arene (L′(Opropyl)8) with [TiCl4] in refluxing toluene afforded, following work-up, a 35:65 mixture (3) of the complex [Ti(NCMe)Cl]2[TiCl(μ-O)]2L′ and the silicone grease derived complex [Ti(NCMe)Cl]2[Ti(μ-O)]2[OSi(CH3)2OSi(CH3)2O]L′ in which the grease replaces two chloride ligands. The molecular structures of 1·2MeCN, 2·7MeCN, and 3·10MeCN have been determined. The complexes were studied using in vitro cell assays and were found to have CC50 values in the range 111-186 μM, i.e. they have low toxicity.

Item Type: Article
Uncontrolled Keywords: inorganic chemistry ,/dk/atira/pure/subjectarea/asjc/1600/1604
Faculty \ School: Faculty of Science > School of Chemistry
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Depositing User: LivePure Connector
Date Deposited: 30 Aug 2019 13:30
Last Modified: 22 Apr 2020 08:09
URI: https://ueaeprints.uea.ac.uk/id/eprint/72073
DOI: 10.1039/c8dt01992d

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