Sex-Specific Responses of Lifespan and Fitness to Variation in Developmental versus Adult Diets in D. melanogaster

Duxbury, Elizabeth M L and Chapman, Tracey (2019) Sex-Specific Responses of Lifespan and Fitness to Variation in Developmental versus Adult Diets in D. melanogaster. The Journals of Gerontology, Series A. ISSN 1079-5006

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Nutritional variation across the lifetime can have significant and sex-specific impacts upon fitness. Using Drosophila melanogaster, we measured these impacts by testing the effects on lifespan and reproductive success of high or low yeast content in developmental versus adult diets, separately for each sex. We tested two hypotheses: that dietary mismatches between development and adulthood are costly and that any such costs are sex-specific. Overall, the results revealed the rich and complex responses of each sex to dietary variation across the lifetime. Contrary to the first hypothesis, dietary mismatches between developmental and adult life stages were not universally costly. Where costs of nutritional variation across the life course did occur, they were sex-, context- and trait-specific, consistent with hypothesis 2. We found effects of mismatches between developmental and adult diets on reproductive success in females but not males. Adult diet was the main determinant of survival, and lifespan was significantly longer on high yeast adult food, in comparison to low, in both sexes. Developing on a high yeast diet also benefited adult female lifespan and reproductive success, regardless of adult diet. In contrast, a high yeast developmental diet was only beneficial for male lifespan when it was followed by low yeast adult food. Adult diet affected mating frequency in opposing directions, with males having higher mating frequency on high and females on low, with no interaction with developmental diet for either sex. The results emphasise the importance of sex differences and of the directionality of dietary mismatches in the responses to nutritional variation.

Item Type: Article
Faculty \ School: Faculty of Science > School of Biological Sciences
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Depositing User: LivePure Connector
Date Deposited: 01 Aug 2019 11:30
Last Modified: 10 Jul 2020 23:59
DOI: 10.1093/gerona/glz175

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