Sleep and brain morphological changes in the eighth decade of life

Aribisala, Benjamin S., Riha, Renata L., Hernandez, Maria Valdez, Maniega, Susana Muñoz, Cox, Simon, Radakovic, Ratko, Taylor, Adele, Pattie, Alison, Corley, Janie, Redmond, Paul, Bastin, Mark E., Starr, John, Deary, Ian and Wardlaw, Joanna M. (2020) Sleep and brain morphological changes in the eighth decade of life. Sleep Medicine Reviews, 65. pp. 152-158. ISSN 1389-9457

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Abstract

Objective Sleep is important for brain health. We analysed associations between usual sleep habits and MRI markers of neurodegeneration (brain atrophy), vascular damage (white matter hyperintensities, WMH) and waste clearance (perivascular spaces, PVS) in older community-dwelling adults. Method We collected self-reported usual sleep duration, quality and medical histories from the Lothian Birth Cohort 1936 (LBC1936) age 76 years and performed brain MRI. We calculated sleep efficiency, measured WMH and brain volumes, quantified PVS, and assessed associations between sleep measures and brain markers in multivariate models adjusted for demographic and medical history variables. Results In 457 subjects (53% males, mean age 76±0.65 years), we found: brain and white matter loss with increased weekend daytime sleep (β=-0.114, P=0.03; β=-0.122, P=0.007 respectively), white matter loss with less efficient sleep (β=0.132, P=0.011) and PVS increased with interrupted sleep (OR 1.84 95% CI, P=0.025). Conclusion Cross-sectional associations of sleep parameters with brain atrophy and more PVS suggest adverse relationships between usual sleep habits and brain health in older people that should be evaluated longitudinally.

Item Type: Article
Uncontrolled Keywords: ageing,brain atrophy,cerebrovascular disease,magnetic resonance imaging,perivascular spaces,sleep,apnea,small vessel disease,associations,quality,white-matter,slow-wave sleep,dwelling older-adults,virchow-robin spaces,duration,age,medicine(all) ,/dk/atira/pure/subjectarea/asjc/2700
Faculty \ School: Faculty of Medicine and Health Sciences > School of Health Sciences
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Depositing User: LivePure Connector
Date Deposited: 30 Jul 2019 11:30
Last Modified: 26 Mar 2020 01:27
URI: https://ueaeprints.uea.ac.uk/id/eprint/71840
DOI: 10.1016/j.sleep.2019.07.015

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