Plasma vitamin C levels: risk factors for deficiency and association with self-reported functional health in the European Prospective Investigation into Cancer-Norfolk

McCall, Stephen, Clark, Allan ORCID: https://orcid.org/0000-0003-2965-8941, Luben, Robert N, Wareham, Nicholas, Khaw, Kay-Tee and Myint, Phyo (2019) Plasma vitamin C levels: risk factors for deficiency and association with self-reported functional health in the European Prospective Investigation into Cancer-Norfolk. Nutrients, 11 (7). ISSN 2072-6643

Preview	PDF (Accepted_Version) - Accepted Version Available under License Creative Commons Attribution. Download (1MB) | Preview
Preview	PDF (nutrients-11-01552) - Published Version Available under License Creative Commons Attribution. Download (260kB) | Preview

Abstract

Abstract Background: To investigate the demographic and lifestyles factors associated with vitamin C deficiency and to examine the association between plasma vitamin C level and self-reported physical functional health. Methods: A population-based cross-sectional study using the European Prospective Investigation into Cancer-Norfolk study. Plasma vitamin C level <11 µmol/L indicated vitamin C deficiency. Unconditional logistic regression models assessed the association between vitamin C deficiency and potential risk factors. Associations between quartiles of vitamin C and self-reported functional health measured by Short Form-36 were assessed. Results: After adjustment, vitamin C deficiency was associated with older age, being male, lower physical activity, smoking, more socially deprived area (Townsend index) and a lower educational attainment. Those in the lowest quartile of vitamin C compared to the highest were more likely to score in the lowest decile of physical function [adjusted odd ratio(aOR): 1.43 (95%CI:1.21-1.70)], bodily pain[aOR: 1.29 (95% CI: 1.07-1.56)], general health[aOR: 1.4 (95%CI:1.18-1.66)] and vitality[aOR: 1.23 (95%CI: 1.04-1.45)] SF-36 scores. Conclusions: Simple public health interventions should be aimed at populations with risk factors for vitamin C deficiency. Poor self-reported functional health was associated with lower plasma vitamin C levels, which may reflect symptoms of latent scurvy.

Item Type:	Article
Uncontrolled Keywords:	sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Epidemiology and Public Health Faculty of Medicine and Health Sciences > Research Groups > Norwich Clinical Trials Unit Faculty of Medicine and Health Sciences > Research Groups > Health Services and Primary Care Faculty of Medicine and Health Sciences > Research Groups > Public Health and Health Services Research (former - to 2023) Faculty of Medicine and Health Sciences > Research Centres > Population Health
Depositing User:	LivePure Connector
Date Deposited:	03 Jul 2019 09:30
Last Modified:	19 Oct 2023 02:29
URI:	https://ueaeprints.uea.ac.uk/id/eprint/71619
DOI:	10.3390/nu11071552

Downloads

Actions (login required)

View Item