Emerging regulators of vascular smooth muscle cell migration

Afewerki, TecLino, Ahmed, Sultan and Warren, Derek (2019) Emerging regulators of vascular smooth muscle cell migration. Journal of Muscle Research and Cell Motility, 40 (2). 185–196. ISSN 0142-4319

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Abstract

Vascular smooth muscle cells (VSMCs) are the predominant cell type in the blood vessel wall and normally adopt a quiescent, contractile phenotype. VSMC migration is tightly controlled, however, disease associated changes in the soluble and insoluble environment promote VSMC migration. Classically, studies investigating VSMC migration have described the influence of soluble factors. Emerging data has highlighted the importance of insoluble factors, including extracellular matrix stiffness and porosity. In this review, we will recap on the important signalling pathways that regulate VSMC migration and reflect on the potential importance of emerging regulators of VSMC function.

Item Type: Article
Faculty \ School: Faculty of Science > School of Pharmacy
Depositing User: LivePure Connector
Date Deposited: 01 Jul 2019 07:30
Last Modified: 09 Nov 2020 00:57
URI: https://ueaeprints.uea.ac.uk/id/eprint/71581
DOI: 10.1007/s10974-019-09531-z

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