A draft genome of Escherichia coli sequence type 127 strain 2009-46

Darling, Aaron E., McKinnon, Jessica, Worden, Paul, Santos, Jerran, Charles, Ian G., Chowdhury, Piklu Roy and Djordjevic, Steven P. (2014) A draft genome of Escherichia coli sequence type 127 strain 2009-46. Gut Pathogens, 6 (1). ISSN 2076-0817

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Abstract

Background: Escherichia coli are a frequent cause of urinary tract infections (UTI) and are thought to have a foodborne origin. E. coli with sequence type 127 (ST127) are emerging pathogens increasingly implicated as a cause of urinary tract infections (UTI) globally. A ST127 isolate (2009-46) resistant to ampicillin and trimethoprim was recovered from the urine of a 56 year old patient with a UTI from a hospital in Sydney, Australia and was characterised here. Results: We sequenced the genome of Escherichia coli 2009-46 using the Illumina Nextera XT and MiSeq technologies. Assembly of the sequence data reconstructed a 5.14 Mbp genome in 89 scaffolds with an N50 of 161 kbp. The genome has extensive similarity to other sequenced uropathogenic E. coli genomes, but also has several genes that are potentially related to virulence and pathogenicity that are not present in the reference E. coli strain. Conclusion: E. coli 2009-46 is a multiple antibiotic resistant, phylogroup B2 isolate recovered from a patient with a UTI. This is the first description of a drug resistant E. coli ST127 in Australia.

Item Type: Article
Uncontrolled Keywords: escherichia coli 2009-46,genome,sequencing,parasitology,microbiology,gastroenterology,infectious diseases,virology ,/dk/atira/pure/subjectarea/asjc/2400/2405
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Depositing User: LivePure Connector
Date Deposited: 11 Jun 2019 16:30
Last Modified: 22 Apr 2020 07:55
URI: https://ueaeprints.uea.ac.uk/id/eprint/71326
DOI: 10.1186/1757-4749-6-32

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