Apathy and functional disability in behavioral variant frontotemporal dementia

Yassuda, Mônica S., Lima da Silva, Thais B., O’Connor, Claire M., Mekala, Shailaja, Alladi, Suvarna, Bahia, Valeria S., Almaral-Carvalho, Viviane, Guimaraes, Henrique C., Caramelli, Paulo, Balthazar, Marcio L. F., Damasceno, Benito, Brucki, Sonia M. D., Nitrini, Ricardo, Hodges, John R., Piguet, Olivier and Mioshi, Eneida (2018) Apathy and functional disability in behavioral variant frontotemporal dementia. Neurology: Clinical Practice, 8 (2). pp. 120-128. ISSN 2163-0402

[thumbnail of Published_Version]
PDF (Published_Version) - Published Version
Download (574kB) | Preview


Background Behavioral variant frontotemporal dementia (bvFTD) has profound consequences on patients and their families. In this multicenter study, we investigated the contribution of cognitive and neuropsychiatric factors to everyday function at different levels of overall functional impairment. Methods In a retrospective cross-sectional study, 109 patients with bvFTD from 4 specialist frontotemporal dementia centers (Australia, England, India, and Brazil) were included. The measures administered evaluated everyday function (Disability Assessment for Dementia [DAD]), dementia staging (Clinical Dementia Rating [CDR]), general cognition (Addenbrooke’s Cognitive Examination–revised [ACE-R]), and neuropsychiatric symptoms (Neuropsychiatric Inventory [NPI]). Patients were then subdivided according to functional impairment on the DAD into mild, moderate, severe, and very severe subgroups. Three separate multiple linear regression analyses were run, where (1) total DAD, (2) basic activities of daily living (BADL), and (3) instrumental activities of daily living (IADL) scores were dependent variables; ACE-R total score and selected NPI domains (agitation/aggression, euphoria, apathy, disinhibition, irritability, aberrant motor behavior) were used as independent variables. Age, sex, education, and country of origin were controlled for in the analyses. Results Cognitive deficits were similar across the mild, moderate, and severe subgroups but significantly worse in the very severe subgroup. NPI domain scores (agitation/aggression, euphoria, apathy, disinhibition, irritability, aberrant motor behavior) did not differ across the DAD subgroups. In the multiple regression analyses, a model including ACE-R and NPI apathy explained 32.5% of the variance for total DAD scores. For IADL, 35.6% of the variance was explained by the ACE-R only. No model emerged for BADL scores. Conclusions Cognitive deficits and apathy are key contributors to functional disability in bvFTD but factors underlying impairment in BADLs remain unclear. Treatments targeting reduction of disability need to address apathy and cognitive impairment to ensure greater efficacy, especially in regards to IADLs.

Item Type: Article
Uncontrolled Keywords: clinical neurology ,/dk/atira/pure/subjectarea/asjc/2700/2728
Faculty \ School: Faculty of Medicine and Health Sciences > School of Health Sciences
UEA Research Groups: Faculty of Medicine and Health Sciences > Research Groups > Dementia & Complexity in Later Life
Faculty of Medicine and Health Sciences > Research Centres > Lifespan Health
Related URLs:
Depositing User: LivePure Connector
Date Deposited: 16 May 2019 14:30
Last Modified: 19 Oct 2023 02:26
URI: https://ueaeprints.uea.ac.uk/id/eprint/71027
DOI: 10.1212/CPJ.0000000000000429


Downloads per month over past year

Actions (login required)

View Item View Item